1-(4-Methoxyphenyl)ethanone hydrazone

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)ethanone hydrazone
• CAS No.: 6310-14-1
• Molecular Formula: C9H12 N2 O
• Molecular Weight: 164.207
• Hs Code.: 2928000090
• NSC Number: 43030
• Nikkaji Number: J818.594H
• Mol file: 6310-14-1.mol

Synonyms:6310-14-1;NSC43030;1-(4-Methoxyphenyl)ethanone hydrazone;NSC 43030;NSC-43030;4'-Methoxyacetophenonehydrazone;SCHEMBL15054199

Chemical Property of 1-(4-Methoxyphenyl)ethanone hydrazone

Chemical Property:

• Vapor Pressure: 0.00268mmHg at 25°C
• Boiling Point: 286.2°C at 760 mmHg
• Flash Point: 126.9°C
• PSA: 47.61000
• Density: 1.05g/cm³
• LogP: 2.07820
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 164.094963011
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=NN)C1=CC=C(C=C1)OC
• Isomeric SMILES: C/C(=N/N)/C1=CC=C(C=C1)OC

Technology Process of 1-(4-Methoxyphenyl)ethanone hydrazone

There total 7 articles about 1-(4-Methoxyphenyl)ethanone hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-methoxyphenyl)ethanone (100-06-1) → 4'-methoxyacetophenone hydrazone (6310-14-1)

Guidance literature:

With toluene-4-sulfonic acid; hydrazine hydrate; In ethanol; at 70 - 80 ℃;

DOI:10.1007/BF02494871

Reference yield: 93.0%

4-methoxyphenylacetylen (768-60-5) → 4'-methoxyacetophenone hydrazone (6310-14-1)

Guidance literature:

With C₅₇H₇₂Au₄Cl₄N₁₂O₄; hydrazine; potassium tetrakis(pentafluorophenyl)borate; In toluene; at 60 ℃; for 12h; Reagent/catalyst; Inert atmosphere;

DOI:10.1021/acs.organomet.7b00712

Reference yield:

2-Bromo-4'-methoxyacetophenone (2632-13-5) → 4'-methoxyacetophenone hydrazone (6310-14-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / N,N-dimethyl-formamide / 12 h

2: potassium hydroxide; hydrazine hydrate / ethylene glycol / 3 h / Heating

With hydrazine hydrate; potassium hydroxide; In ethylene glycol; N,N-dimethyl-formamide; 2: |Wolff-Kishner Reduction;

DOI:10.1002/adsc.201901641

upstream raw materials:

p-Methoxyacetophenone N,N-dimethylhydrazone

1-(4-methoxyphenyl)ethanone

4-methoxyphenylacetylen

2-(4-chlorophenoxy)-1-(4-methoxyphenyl)ethan-1-one

Downstream raw materials:

methyl 4-methoxybenzoate

1-(4-methoxyphenyl)ethanone

7-(4-Methoxy-phenyl)-7-methyl-2,3a,5-triphenyl-3,3a-dihydro-pyrazolo[1,5-c][1,3]oxazine

1-(1-diazoethyl)-4-methoxybenzene

Refernces

• 1、 Campos-Dominguez, Emmanuel,Vasquez-Perez, Jose,Rojas-Lima, Susana,Lopez-Ruiz, Heraclio,Mendoza-Espinosa, Daniel. "Gold(I) complexes bearing ring-fused benzoxazine-derived triazolylidenes and their use in C–N bond-forming processes". . . Retrieved 2020/12/07.
• 2、 Zhu, Dianhu,Lv, Leiyang,Li, Chen-Chen,Ung, Sosthene,Gao, Jian,Li, Chao-Jun. "Umpolung of Carbonyl Groups as Alkyl Organometallic Reagent Surrogates for Palladium-Catalyzed Allylic Alkylation". supporting information. p. 16520 - 16524. Retrieved 2018/11/23.