N-fluoren-4-ylacetohydroxamic acid

Base Information

• Chemical Name: N-fluoren-4-ylacetohydroxamic acid
• CAS No.: 22225-34-9
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.274
• Hs Code.: 2924299090
• Mol file: 22225-34-9.mol

Synonyms:Acetohydroxamicacid, N-fluoren-4-yl- (8CI); N-Fluoren-4-ylacetohydroxamic acid;N-Hydroxy-4-acetamidofluorene; N-Hydroxy-N-4-fluorenylacetamide;N-Hydroxy-N-acetyl-4-aminofluorene

Chemical Property of N-fluoren-4-ylacetohydroxamic acid

Chemical Property:

• Vapor Pressure: 4.51E-09mmHg at 25°C
• Boiling Point: 455.1°C at 760 mmHg
• Flash Point: 229°C
• PSA: 40.54000
• Density: 1.322g/cm³
• LogP: 2.99990

Purity/Quality:

99% ^*data from raw suppliers

N-9H-Fluoren-4-yl-N-hydroxy-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-9H-Fluoren-4-yl-N-hydroxy-acetamide is a strong carcinogen which causes a very low incidence of non-heptic tumors and hepatic clear cell foci in rats.

Technology Process of N-fluoren-4-ylacetohydroxamic acid

There total 4 articles about N-fluoren-4-ylacetohydroxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Aminofluorene (7083-63-8) → N-(Fluorenyl-(4))-acethydroxamsaeure (22225-34-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. H₂O₂, maleic anhydride / CH₂Cl₂ / Heating

2: H₂, Et₃N / Pd-C

With maleic anhydride; hydrogen; dihydrogen peroxide; triethylamine; palladium on activated charcoal; In dichloromethane;

DOI:10.1039/j39690000345

Reference yield:

4-aminofluorenone (4269-15-2) → N-(Fluorenyl-(4))-acethydroxamsaeure (22225-34-9)

Guidance literature:

Multi-step reaction with 3 steps

1: N₂H₄*H₂O, NaOH, HOCH₂CH₂OH / Heating

2: aq. H₂O₂, maleic anhydride / CH₂Cl₂ / Heating

3: H₂, Et₃N / Pd-C

With maleic anhydride; sodium hydroxide; hydrogen; dihydrogen peroxide; hydrazine hydrate; ethylene glycol; triethylamine; palladium on activated charcoal; In dichloromethane;

DOI:10.1039/j39690000345

Reference yield:

4-Nitroso-fluoren (22225-33-8) + acetyl chloride (75-36-5) → N-(Fluorenyl-(4))-acethydroxamsaeure (22225-34-9)

Guidance literature:

With hydrogen; acetic anhydride; triethylamine; palladium on activated charcoal; In ethyl acetate;

DOI:10.1039/j39700002497

upstream raw materials:

4-Nitroso-fluoren

acetyl chloride

4-nitrofluorene

4-Aminofluorene