L 743725

Base Information

Chemical Name:L 743725
CAS No.:154801-74-8
Molecular Formula:C14H9 Cl F3 N O2
Molecular Weight:315.679
Hs Code.:
Mol file:154801-74-8.mol

Synonyms:2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (4R)- (9CI);2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-, (R)-;(R)-Efavirenz; L 743725

Suppliers and Price of L 743725

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ent-Efavirenz
2.5mg
$ 460.00

TRC
ent-Efavirenz
2.5mg
$ 185.00

Medical Isotopes, Inc.
entEfavirenz
12.5 mg
$ 2200.00

American Custom Chemicals Corporation
ENT EFAVIRENZ 95.00%
25MG
$ 1963.50

American Custom Chemicals Corporation
ENT EFAVIRENZ 95.00%
2.5MG
$ 715.00

American Custom Chemicals Corporation
ENT EFAVIRENZ 95.00%
10MG
$ 269.85

Total 7 raw suppliers

Chemical Property of L 743725

Chemical Property:

Vapor Pressure:8.53E-05mmHg at 25°C
Melting Point:125-127°C
Boiling Point:340.6°C at 760 mmHg
PKA:10.24±0.40(Predicted)
Flash Point:159.8°C
PSA：38.33000
Density:1.53g/cm³
LogP:4.21110
Storage Temp.:-20°C Freezer

Purity/Quality:

97% ^*data from raw suppliers

ent-Efavirenz ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses A nonnucleoside HIV-1 reverse transcriptase inhibitor. Antiviral

Technology Process of L 743725

There total 12 articles about L 743725 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 32315-10-9
bis(trichloromethyl) carbonate

: 1236354-27-0
(S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate

: 154801-74-8,154635-17-3
(R)-efavirenz

Guidance literature:: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate; With sodium carbonate; In n-heptane; water; ethyl acetate; at 15 ℃; for 0.333333h; pH=6.1;

bis(trichloromethyl) carbonate; at 12 ℃; for 1h; Product distribution / selectivity;

Reference yield: 95.7%

: 75-44-5
phosgene

: 1236354-27-0
(S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate

: 154801-74-8,154635-17-3
(R)-efavirenz

Guidance literature:: (S)-2-(2-amino-5-chlorophenyl)-4-cyclopropyl-1,1,1-trifluorobut-3-yn-2-ol methanesulfonate; With sodium carbonate; In n-heptane; water; ethyl acetate; at 15 ℃; for 0.333333h; pH=7.2;

phosgene; at 12 - 20 ℃; for 1.5h; Product distribution / selectivity;