4-Phenoxyquinazoline

Base Information

• Chemical Name: 4-Phenoxyquinazoline
• CAS No.: 16347-97-0
• Molecular Formula: C14H10 N2 O
• Molecular Weight: 222.246
• NSC Number: 94561
• UNII: U4M07V35E8
• DSSTox Substance ID: DTXSID40167601
• Nikkaji Number: J2.322.922F
• Wikidata: Q83037009
• ChEMBL ID: CHEMBL1889421
• Mol file: 16347-97-0.mol

Synonyms:4-Phenoxyquinazoline;16347-97-0;Quinazoline, 4-phenoxy-;U4M07V35E8;NSC94561;NSC 94561;UNII-U4M07V35E8;MLS002695245;NSC-94561;F1070-0016;4-Phenoxy-quinazoline;Phenyl 4-quinazolinyl ether;NCIOpen2_006166;SCHEMBL3979754;CHEMBL1889421;DTXSID40167601;HMS3087M09;AKOS002348645;CCG-280252;SMR000797665

Chemical Property of 4-Phenoxyquinazoline

Chemical Property:

• Vapor Pressure: 2.04E-05mmHg at 25°C
• Boiling Point: 372.6°C at 760 mmHg
• Flash Point: 135.7°C
• Density: 1.23g/cm³
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 222.079312947
• Heavy Atom Count: 17
• Complexity: 240

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OC2=NC=NC3=CC=CC=C32

Technology Process of 4-Phenoxyquinazoline

There total 10 articles about 4-Phenoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

4-Hydroxyquinazoline (491-36-1) + phenol (108-95-2,27073-41-2) → 4-phenoxy-quinazoline (16347-97-0)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 10h;

DOI:10.1021/ol060815y DOI:10.1021/jo7020373

Reference yield: 84.0%

4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)quinazoline (1003015-89-1) + phenol (108-95-2,27073-41-2) → 4-phenoxy-quinazoline (16347-97-0)

Guidance literature:

With caesium carbonate; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jo7020373

Reference yield: 84.0%

4-(1H-benzo[d][1,2,3]triazol-1-yloxy)quinazoline (897930-10-8) + phenol (108-95-2,27073-41-2) → 4-phenoxy-quinazoline (16347-97-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;

DOI:10.1021/jo7020373

upstream raw materials:

4-chloroquinazoline

phenol

4-Hydroxyquinazoline

4-(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)quinazoline

Downstream raw materials:

4-Aminoquinazoline

Glycorin

4-phenoxy-quinazoline-1-oxide

1-hydroxy-4-phenoxy-1H-quinazolin-2-one