N-(2-BROMO-3,4,5-TRIMETHOXYBENZYLIDENE)CYCLOHEXYLAMINE

Base Information

• Chemical Name: N-(2-BROMO-3,4,5-TRIMETHOXYBENZYLIDENE)CYCLOHEXYLAMINE
• CAS No.: 73252-56-9
• Molecular Formula: C16H22BrNO3
• Molecular Weight: 356.2548
• Mol file: 73252-56-9.mol

Synonyms:(2-bromo-3,4,5-trimethoxy-benzylidene)-cyclohexylamine;1-(2-bromo-3,4,5-trimethoxy-phenyl)-N-cyclohexyl-methanimine;2-bromo-3,4,5-trimethoxybenzaldehyde cyclohexylimine;

Chemical Property of N-(2-BROMO-3,4,5-TRIMETHOXYBENZYLIDENE)CYCLOHEXYLAMINE

Chemical Property:

• Vapor Pressure: 2.77E-07mmHg at 25°C
• Boiling Point: 432.6°Cat760mmHg
• Flash Point: 215.4°C
• PSA: 40.05000
• Density: 1.33g/cm³
• LogP: 4.22650

Purity/Quality:

99% ^*data from raw suppliers

N-(2-BROMO-3,4,5-TRIMETHOXYBENZYLIDENE)CYCLOHEXYLAMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-BROMO-3,4,5-TRIMETHOXYBENZYLIDENE)CYCLOHEXYLAMINE

There total 2 articles about N-(2-BROMO-3,4,5-TRIMETHOXYBENZYLIDENE)CYCLOHEXYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromo-3,4,5-tri-methoxybenzaldehyde (35274-53-4) + cyclohexylamine (108-91-8,157973-60-9) → (2-bromo-3,4,5-trimethoxy-benzylidene)-cyclohexylamine (73252-56-9)

Guidance literature:

In toluene;

DOI:10.1016/j.tetlet.2007.04.103

Reference yield:

3,4,5-trimethoxy-benzaldehyde (86-81-7) → (2-bromo-3,4,5-trimethoxy-benzylidene)-cyclohexylamine (73252-56-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / NBS / acetonitrile

2: 88 percent / toluene

With N-Bromosuccinimide; In toluene; acetonitrile;

DOI:10.1016/j.tetlet.2007.04.103

Reference yield: 77.0%

4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne (894762-72-2) + (2-bromo-3,4,5-trimethoxy-benzylidene)-cyclohexylamine (73252-56-9) → 4'-benzyloxy-2'-[1,1-(ethylenedioxy)ethyl]-4,5,6-trimethoxy-biphenyl-2-carbaldehyde (894762-68-6)

Guidance literature:

4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.25h;

In tetrahydrofuran; at -78 ℃; for 0.5h;

(2-bromo-3,4,5-trimethoxy-benzylidene)-cyclohexylamine; In tetrahydrofuran; at -78 - 45 ℃; for 64h; Further stages.;

DOI:10.1016/j.tetlet.2007.04.103

upstream raw materials:

2-bromo-3,4,5-tri-methoxybenzaldehyde

cyclohexylamine

3,4,5-trimethoxy-benzaldehyde

Downstream raw materials:

4'-benzyloxy-2'-[1,1-(ethylenedioxy)ethyl]-4,5,6-trimethoxy-biphenyl-2-carbaldehyde

2'-acetyl-4'-benzyloxy-4,5,6-trimethoxybiphenyl-2-carbaldehyde

3-benzyloxy-9,10,11-trimethoxy-dibenzo[a,c]cyclohepten-5-one

4,5-methylenedioxy-4',5',6'-trimethoxy-1,1'-biphenyl-2,2'-dicarboxaldehyde