4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne

Base Information

• Chemical Name: 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne
• CAS No.: 894762-72-2
• Molecular Formula: C₁₇H₁₇BrO₃
• Molecular Weight: 349.224
• Mol file: 894762-72-2.mol

Synonyms:4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne

Chemical Property of 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne

Chemical Property:

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne

There total 4 articles about 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone (105805-16-1) + ethylene glycol (107-21-1) → 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne (894762-72-2)

Guidance literature:

With toluene-4-sulfonic acid; In toluene;

DOI:10.1016/j.tetlet.2007.04.103

Reference yield:

1-[3-(phenylmethoxy)phenyl]ethan-1-one (34068-01-4) → 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne (894762-72-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NBS / acetonitrile

2: 92 percent / TsOH / toluene

With N-Bromosuccinimide; toluene-4-sulfonic acid; In toluene; acetonitrile;

DOI:10.1016/j.tetlet.2007.04.103

Reference yield:

3-Hydroxyacetophenone (121-71-1) → 4-benzyloxy-2-[1,1-(ethylenedioxy)ethyl]-bromobenzne (894762-72-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / K₂CO₃ / dimethylformamide

2: 70 percent / NBS / acetonitrile

3: 92 percent / TsOH / toluene

With N-Bromosuccinimide; potassium carbonate; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene; acetonitrile;

DOI:10.1016/j.tetlet.2007.04.103

upstream raw materials:

1-[2-bromo-5-(phenylmethoxy)phenyl]ethanone

ethylene glycol

1-[3-(phenylmethoxy)phenyl]ethan-1-one

3-Hydroxyacetophenone

Downstream raw materials:

4'-benzyloxy-2'-[1,1-(ethylenedioxy)ethyl]-4,5,6-trimethoxy-biphenyl-2-carbaldehyde

4-benzyloxy-2-(2-methyl-[1,3]dioxolan-2-yl)-phenylboronic acid

3-benzyloxy-9,10,11-trimethoxy-dibenzo[a,c]cyclohepten-5-one

2'-acetyl-4'-benzyloxy-4,5,6-trimethoxybiphenyl-2-carbaldehyde