desacetylpractolol

Base Information

• Chemical Name: desacetylpractolol
• CAS No.: 27684-79-3
• Molecular Formula: C12H20 N2 O2
• Molecular Weight: 224.303
• Mol file: 27684-79-3.mol

Synonyms:2-Propanol,1-(p-aminophenoxy)-3-(isopropylamino)- (8CI);1-(4-Aminophenoxy)-2-hydroxy-3-(isopropylamino)propane;1-(4-Aminophenoxy)-3-(isopropylamino)-2-propanol;4-[2-Hydroxy-3-(isopropylamino)propoxy]aniline; Desacetylpractolol

Chemical Property of desacetylpractolol

Chemical Property:

• Vapor Pressure: 2.32E-07mmHg at 25°C
• Boiling Point: 407.2°Cat760mmHg
• Flash Point: 200°C
• Density: 1.092g/cm³

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of desacetylpractolol

There total 6 articles about desacetylpractolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

practolol (6673-35-4) → 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]benzenamine (27684-79-3)

Guidance literature:

With hydrogenchloride; water; Heating;

DOI:10.1002/(SICI)1099-0690(200003)2000:6<1007::AID-EJOC1007>3.0.CO;2-I

Reference yield: 72.0%

1-(4-Phenylazophenoxy)-3-isopropylaminopropanol-2 → 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]benzenamine (27684-79-3)

Guidance literature:

With hydrogen; nickel; In methanol;

DOI:10.1007/BF01146183

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]benzenamine (27684-79-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1 N NaOH / 10 h

2: ethanol / 4 h / Heating

3: H₂ / 10percent Pd/C / ethanol / 1 h / 760 Torr

With sodium hydroxide; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1021/jm00109a007

upstream raw materials:

practolol

4-nitro-phenol

4-nitrophenyl 2-oxiranylmethyl ether

Downstream raw materials:

2-Chloro-4-<4-(3'-isopropylamino-2'-oxypropoxy)phenylamino>-6,7-dimethoxyquinazoline

N-[4-(2-hydroxy-3-isopropylamino-propoxy)-phenyl]-3-(4-phenyl-piperazin-1-yl)-propionamide

1-(4-Ethoxycarbonylaminophenoxy)-2-hydroxy-3-isopropylaminopropan

4-Anilino-5-chloro-2-{4-[2-hydroxy-3-(isopropylamino)propoxy]anilino}pyrimidine

Refernces

• 1、 Apparu, Marcel,Ben Tiba, Younes,Leo, Pierre-Marc,Fagret, Daniel. "Synthesis of potentially β-blocking practolol derivatives: (E + Z)-3- [4-(3-iodoprop-2-enyloxycarbonylamino)phenoxy]-1-(isopropylamino)propan-2-ol". . p. 1007 - 1012. Retrieved 2007/10/03.
• 2、 Glozman, O. M.,Orlova, E. K.,Agavelyan, E. S.,Ismailov, Sh. I.,Nerobkova, L. N.,et al.. "SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 1-PHENOXY-3-AMINOPROPANOL-2-DERIVATIVES". . p. 197 - 200. Retrieved 2007/10/02.