Practolol

Base Information

• Chemical Name: Practolol
• CAS No.: 6673-35-4
• Deprecated CAS: 23313-50-0
• Molecular Formula: C14H22N2O3
• Molecular Weight: 266.34
• Hs Code.: 2924299090
• European Community (EC) Number: 229-712-1
• UNII: SUG9176GRW
• DSSTox Substance ID: DTXSID0021179
• Nikkaji Number: J8.428J
• Wikipedia: Practolol
• Wikidata: Q7237376
• NCI Thesaurus Code: C76556
• Pharos Ligand ID: MYM8XBURZV6G
• Metabolomics Workbench ID: 146001
• ChEMBL ID: CHEMBL6995
• Mol file: 6673-35-4.mol

Synonyms:Dalzic;Eralzdin Practolol;ICI 50172;ICI-50172;ICI50172;Practolol;Practolol, Eralzdin

Chemical Property of Practolol

Chemical Property:

• Vapor Pressure: 1.47E-10mmHg at 25°C
• Melting Point: 134-136° (BuOAc)
• Refractive Index: 1.5110 (estimate)
• Boiling Point: 493.6 ºC at 760 mmHg
• PKA: pKa 9.5 (Uncertain)
• Flash Point: 252.3 ºC
• PSA: 70.59000
• Density: 1.127 g/cm³
• LogP: 1.84660
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 266.16304257
• Heavy Atom Count: 19
• Complexity: 263

Purity/Quality:

95-99% ^*data from raw suppliers

rac Practolol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)NCC(COC1=CC=C(C=C1)NC(=O)C)O
• Uses: Practolol is a selective adrenergic β-receptor blocking drug with antihyperstensive activity. Practolol has been used in the emergency treatment of cardiac arrhythmias. N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE is a selective adrenergic β-receptor blocking drug with antihyperstensive activity. N-[4-[2-HYDROXY-3-[(1-METHYLETHYL)AMINO]PROPOXY]PHENYL]ACETAMIDE has been used in the emergency treatment of cardiac arrhythmias.
• Therapeutic Function: Antiarrhythmic

Technology Process of Practolol

There total 7 articles about Practolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(4-acetamidophenoxy)-2,3-epoxypropane (6597-75-7) + isopropylamine (75-31-0) → practolol (6673-35-4)

Guidance literature:

In isopropyl alcohol; Heating;

DOI:10.1016/S0957-4166(00)00254-8

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → practolol (6673-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0 °C

1.2: 75 percent / dimethylformamide

2.1: propan-2-ol / Heating

With sodium hydride; In N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Metallation / 1.2: Alkylation / 2.1: Ring cleavage;

DOI:10.1016/S0957-4166(00)00254-8

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → practolol (6673-35-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / 5 h / 120 °C

2: isopropyl alcohol / 6 h / 100 °C

With potassium carbonate; In isopropyl alcohol;

DOI:10.1002/anie.202100801

upstream raw materials:

1-(4-acetamidophenoxy)-2,3-epoxypropane

isopropylamine

4-acetaminophenol

N-Phenylacetohydroxamic acid

Downstream raw materials:

(+)-Practolol

(-)-Practolol

4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]benzenamine

N-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-N-methyl-acetamide

Refernces

• 1、 -. "The curved blade of the needle and needle cover for preventing mispuncture mispuncture prevention known airfoil with curved needle with a needle cover having a chemical injection device". . . Retrieved 2007/10/11.
• 2、 -. "ANTIHYPERTENSIVE THERAPY". . . Retrieved 2009/09/08.