4,4'-DICHLOROBENZOIN

Base Information

• Chemical Name: 4,4'-DICHLOROBENZOIN
• CAS No.: 4254-20-0
• Molecular Formula: C14H10 Cl2 O2
• Molecular Weight: 281.138
• Hs Code.: 2914700090
• Mol file: 4254-20-0.mol

Synonyms:Benzoin,4,4'-dichloro- (6CI,7CI,8CI); (?à)-4,4'-Dichlorobenzoin; 1,2-Bis(4-chlorophenyl)-2-hydroxyethanone; 2-Hydroxy-1,2-bis(4-chlorophenyl)ethanone;4,4'-Dichlorobenzoin; NSC 364; NSC 58308; p,p'-Dichlorobenzoin

Chemical Property of 4,4'-DICHLOROBENZOIN

Chemical Property:

• Vapor Pressure: 1.74E-08mmHg at 25°C
• Melting Point: 88 °C
• Boiling Point: 439.1°Cat760mmHg
• PKA: 11.62±0.20(Predicted)
• Flash Point: 219.4°C
• PSA: 37.30000
• Density: 1.379g/cm³
• LogP: 3.90970

Purity/Quality:

99% ^*data from raw suppliers

1,2-Bis(4-chlorophenyl)-2-hydroxyethanone 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4'-DICHLOROBENZOIN

There total 40 articles about 4,4'-DICHLOROBENZOIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

α-benzyl-4,4'-dichlorobenzoin → 4,4'-dichlorobenzoin (4254-20-0) + 4'-chloro-2-phenylacetophenone (1889-71-0)

Guidance literature:

With tetra-n-butylammonium cyanide; In tetrahydrofuran; for 1.5h; Ambient temperature;

DOI:10.1248/cpb.46.6

Reference yield: 99.0%

4-chlorobenzaldehyde (104-88-1) → 4,4'-dichlorobenzoin (4254-20-0)

Guidance literature:

With 1,3-dimethylbenzimidazolium Iodide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; for 2h; Heating;

DOI:10.1248/cpb.42.2633

Reference yield: 97.0%

4,4'-dichlorobenzil (3457-46-3,88372-92-3) → 4,4'-dichlorobenzoin (4254-20-0)

Guidance literature:

With sodium hydrogen selenide; acetic acid; In tetrahydrofuran; ethanol; for 0.5h; Ambient temperature;

DOI:10.1080/00397919208021624

upstream raw materials:

potassium cyanide

4-chlorobenzaldehyde

diethyl ether

triphenylmethyl bromide

Downstream raw materials:

2-chloro-1,2-bis(4-chlorophenyl)ethanone

4,4'-dichlorobenzil

(α-methyl-α-hydroxy-4-chlorobenzyl)-(4-chlorophenyl)-ketone

1,2-Bis-(4-chloro-phenyl)-2-methoxy-propan-1-one

Refernces

• 1、 Cui, Fan,Dou, Letian,Yang, Qin,Yu, Yi,Niu, Zhiqiang,Sun, Yuchun,Liu, Hao,Dehestani, Ahmad,Schierle-Arndt, Kerstin,Yang, Peidong. "Benzoin Radicals as Reducing Agent for Synthesizing Ultrathin Copper Nanowires". . p. 3027 - 3032. Retrieved 2017.
• 2、 Onida, Killian,Haddleton, Alice J.,Norsic, Sébastien,Boisson, Christophe,D'Agosto, Franck,Duguet, Nicolas. "Organocatalytic Synthesis of Substituted Vinylene Carbonates". supporting information. p. 5129 - 5137. Retrieved 2021/09/18.
• 3、 Chilamakuru, Naresh Babu,Mallela, Vijaya Jyothi,Peraman, Ramalingam,Shaik, Shakir Basha,Simham, Venu,Singirisetty, Triveni. "Development of Imidazoline-2-one Derivatives as Potential Antifungal and Anthelminthic Agents: in silico and in vitro Evaluation". . p. 423 - 433. Retrieved 2021/11/24.