Technology Process of 5-Aza-2,8,9-trioxa-1-bismabicyclo(3.3.3)undecane
There total 3 articles about 5-Aza-2,8,9-trioxa-1-bismabicyclo(3.3.3)undecane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
toluene;
byproducts: H2O; under inert atm., 5 equiv. of the amine, reflux for 5 d; soln. was filtered, evapd., recrystn. from hot toluene at room temp., elem. anal,;
DOI:10.1016/j.inoche.2006.09.012
- Guidance literature:
-
With
nitric acid; NaOH; NaOEt;
In
water;
Bi(NO3)3 dissolved in dilute nitric acid, aq. soln. of NaOH added under vigorous stiring, ppt. filtered off and added to soln. of EtONa in EtOH,triethanolamine added, heated to 65-70°C overnight; allowed to cool to room temp., charcoal added and filtered through silica, filtrate diluted with MeOH, allowed to stand for several weeks;
DOI:10.1016/S0020-1693(02)01381-6