P-TOLYLAMINO-ACETIC ACID

Base Information

• Chemical Name: P-TOLYLAMINO-ACETIC ACID
• CAS No.: 21911-69-3
• Molecular Formula: C9H11 N O2
• Molecular Weight: 165.192
• Hs Code.: 2922499990
• Mol file: 21911-69-3.mol

Synonyms:Glycine,N-p-tolyl- (6CI,7CI,8CI); (p-Tolylamino)acetic acid; 2-(p-Tolylamino)aceticacid; N-(4-Methylphenyl)glycine; N-(p-Methylphenyl)glycine; N-(p-Tolyl)glycine;NSC 50584; p-Toluidinoacetic acid

Chemical Property of P-TOLYLAMINO-ACETIC ACID

Chemical Property:

• Vapor Pressure: 8.35E-06mmHg at 25°C
• Boiling Point: 359.8°Cat760mmHg
• Flash Point: 171.4°C
• PSA: 49.33000
• Density: 1.211g/cm³
• LogP: 1.56450

Purity/Quality:

98%min ^*data from raw suppliers

N-(4-methylphenyl)glycine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of P-TOLYLAMINO-ACETIC ACID

There total 12 articles about P-TOLYLAMINO-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

p-toluidine (106-49-0,12221-03-3) + ethyl bromoacetate (105-36-2) → N-(p-tolyl)glycine (21911-69-3)

Guidance literature:

p-toluidine; ethyl bromoacetate; With potassium carbonate; for 1.5h; Milling;

With potassium hydroxide; for 1.5h; Milling;

DOI:10.1039/c9cc04673a

Reference yield: 85.0%

p-toluidine (106-49-0,12221-03-3) + chloroacetic acid (79-11-8) → N-(p-tolyl)glycine (21911-69-3)

Guidance literature:

With sodium hydroxide; In water; for 0.333333h; Reflux;

Reference yield: 75.0%

ethyl 2-(p-tolylamino)acetate (21911-68-2) → N-(p-tolyl)glycine (21911-69-3)

Guidance literature:

With sodium hydroxide; for 0.5h; Heating;

DOI:10.1016/j.ejmech.2007.08.002

upstream raw materials:

ethyl 2-(p-tolylamino)acetate

p-toluidine

chloroacetic acid

1-methyl-4-nitrobenzene

Downstream raw materials:

N-[(2-chloro-4-methyl-phenoxy)-acetyl]-N-p-tolyl-glycine

2,2'-(p-tolylazanediyl)diacetic acid

N-[(4-chloro-phenoxy)-acetyl]-N-p-tolyl-glycine

1-(4-methylphenyl)hydantoin