2,2,4,6-Tetramethyl-1,2-dihydroquinoline

Base Information

• Chemical Name: 2,2,4,6-Tetramethyl-1,2-dihydroquinoline
• CAS No.: 1810-78-2
• Molecular Formula: C13H17N
• Molecular Weight: 187.285
• NSC Number: 161577
• DSSTox Substance ID: DTXSID00303785
• Nikkaji Number: J39.110G
• Wikidata: Q82049245
• ChEMBL ID: CHEMBL1371492
• Mol file: 1810-78-2.mol

Synonyms:2,2,4,6-tetramethyl-1,2-dihydroquinoline;1810-78-2;Quinoline, 1,2-dihydro-2,2,4,6-tetramethyl-;C13H17N;2,2,4,6-tetramethyl-1H-quinoline;NSC161577;MLS000054501;SCHEMBL941508;CHEMBL1371492;DTXSID00303785;DTMCOYOYXVFCKJ-UHFFFAOYSA-N;HMS2495I09;STK870733;AKOS000270104;NSC-161577;SMR000060862;1,2-Dihydro-2,2,4,6-tetramethylquinoline;CS-0282055;Z56801290

Chemical Property of 2,2,4,6-Tetramethyl-1,2-dihydroquinoline

Chemical Property:

• Vapor Pressure: 0.00299mmHg at 25°C
• Boiling Point: 284.4°Cat760mmHg
• Flash Point: 127.2°C
• Density: 0.944g/cm³
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 187.136099547
• Heavy Atom Count: 14
• Complexity: 252

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)NC(C=C2C)(C)C

Technology Process of 2,2,4,6-Tetramethyl-1,2-dihydroquinoline

There total 1 articles about 2,2,4,6-Tetramethyl-1,2-dihydroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluidine hydrochloride (540-23-8) + p-toluidine (106-49-0,12221-03-3) + acetone (67-64-1) → 2,2,4,6-tetramethyl-1,2-dihydroquinoline (1810-78-2) + 2,4,6-trimethylquinoline (2243-89-2)

Guidance literature:

Reference yield: 45.0%

2,2,4,6-tetramethyl-1,2-dihydroquinoline (1810-78-2) + 4-Nitrophenacyl bromide (99-81-0) → 1-(4-nitro-phenyl)-2-(2,2,4,6-tetramethyl-2H-quinolin-1-yl)-ethanone

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 60 - 80 ℃; for 72h;

DOI:10.1023/A:1023914810461

Reference yield: 40.0%

2,2,4,6-tetramethyl-1,2-dihydroquinoline (1810-78-2) + 4-Nitrophenacyl bromide (99-81-0) → 4,4,6,8-tetramethyl-1-(4-nitro-phenyl)-4H-pyrrolo[3,2,1-ij]quinoline

Guidance literature:

In N,N-dimethyl acetamide; for 30h; Heating;

DOI:10.1023/A:1023914810461

upstream raw materials:

p-toluidine hydrochloride

p-toluidine

acetone

Downstream raw materials:

2,2,4,6-tetramethyl-1,2,3,4-tetrahydro-quinoline

2,4,6-trimethylquinoline

methane

4,4,8-trimethyl-2,3-dithiolo[5,4-c]-quinoline-1-thione