2,4,6-Trimethylquinoline

Base Information

• Chemical Name: 2,4,6-Trimethylquinoline
• CAS No.: 2243-89-2
• Molecular Formula: C12H13N
• Molecular Weight: 171.242
• Hs Code.: 2933499090
• European Community (EC) Number: 218-823-0
• UNII: 2HX43GP9TU
• DSSTox Substance ID: DTXSID50176961
• Nikkaji Number: J134.634B
• Wikidata: Q27254772
• Mol file: 2243-89-2.mol

Synonyms:2,4,6-Trimethylquinoline;2243-89-2;Quinoline, 2,4,6-trimethyl-;UNII-2HX43GP9TU;2HX43GP9TU;EINECS 218-823-0;2,4,6-Trimethylquinoline #;F2124-0970;SCHEMBL3531515;DTXSID50176961;HMS1661P09;AKOS000528350;SB67424;FT-0609912;Q27254772

Chemical Property of 2,4,6-Trimethylquinoline

Chemical Property:

• Vapor Pressure: 0.00594mmHg at 25°C
• Melting Point: 68°C
• Refractive Index: 1.6
• Boiling Point: 281.8 °C at 760 mmHg
• Flash Point: 115.9 °C
• PSA: 12.89000
• Density: 1.034 g/cm³
• LogP: 3.16000
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 171.104799419
• Heavy Atom Count: 13
• Complexity: 178

Purity/Quality:

98%min ^*data from raw suppliers

2,4,6-trimethylquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC2=C(C=C1)N=C(C=C2C)C

Technology Process of 2,4,6-Trimethylquinoline

There total 24 articles about 2,4,6-Trimethylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3-penten-2-one (625-33-2) + p-toluidine (106-49-0,12221-03-3) → 2,4,6-trimethylquinoline (2243-89-2)

Guidance literature:

With phosphomolybdic acid; sodium dodecyl-sulfate; In water; toluene; at 80 ℃; for 0.833333h;

DOI:10.1080/00397910903245141

Reference yield: 67.0%

dimethyl sulfoxide (67-68-5,8070-53-9) → 2,6-dimethylquinoline (877-43-0) + 2,4,6-trimethylquinoline (2243-89-2)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 70 ℃; for 3.5h;

DOI:10.1248/cpb.34.1917

Reference yield: 20.0%

(2R,3S)-3-Iodo-2,4,6-trimethyl-1,2,3,4-tetrahydro-quinoline → 2,4,6-trimethylquinoline (2243-89-2)

Guidance literature:

With sodium thiosulfate; In water;

DOI:10.1023/A:1015342406252

upstream raw materials:

2,2,4,6-tetramethyl-1,2-dihydroquinoline

4-[(4-methylphenyl)amino]pent-3-en-2-one

p-toluidine

ethylene glycol

Downstream raw materials:

2,4,6-trimethyl-5,6,7,8-tetrahydro-quinoline

4,6-dimethyl-2-(p-N,N-dimethylaminostyryl)quinoline

N,N-diethyl-4-[trans-2-(4,6-dimethyl-[2]quinolyl)-vinyl]-aniline

4-benzoyloxy-2,4,6-trimethyl-cyclohexa-2,5-dienone

Refernces

• 1、 Bonner,Lockhart. "-". . p. 3963. Retrieved 1959.
• 2、 Gataullin,Minnigulov,Fatykhov,Spirikhin,Abdrakhmanov. "Reactions of N- and C-alkenylanilines: III. Synthesis and cyclization of substituted 2-(1-methyl-2-butenyl)anilines". . p. 31 - 37. Retrieved 2007/10/03.