Sodium phenylpyruvate

Base Information

• Chemical Name: Sodium phenylpyruvate
• CAS No.: 114-76-1
• Molecular Formula: C9H8O3.Na
• Molecular Weight: 186.143
• Hs Code.: 2918300090
• Mol file: 114-76-1.mol

Synonyms:Benzenepropanoicacid, a-oxo-, sodium salt (9CI);Pyruvicacid, phenyl-, sodium salt (8CI);Phenylpyroracemic acid sodium salt;Phenylpyruvic acid sodium salt;Sodium 3-phenyl-2-oxopropionate;b-Phenylpyruvic acid sodium salt;Sodium b-phenylpyruvate;

Chemical Property of Sodium phenylpyruvate

Chemical Property:

• Appearance/Colour: White powder
• Vapor Pressure: 0.000546mmHg at 25°C
• Melting Point: >300 °C(lit.)
• Boiling Point: 299.1 °C at 760 mmHg
• Flash Point: 148.9 °C
• PSA: 57.20000
• Density: 1.257g/cm3
• LogP: -0.45190
• Storage Temp.: 2-8°C
• Water Solubility.: Soluble in water

Purity/Quality:

99% ^*data from raw suppliers

Sodium phenylpyruvate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Sodium phenylpyruvate is a substrate for phenylpyruvate decarboxylase and phenylpyruvate tautomerase.It inhibits amino acid formation and depresses oxygen consumption. Phenylpyruvic acid, sodium salt is a substrate for phenylpyruvate decarboxylase and phenylpyruvate tautomerase.

Technology Process of Sodium phenylpyruvate

There total 7 articles about Sodium phenylpyruvate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(Z)-5'-benzylidenecyclohexanespiro-2'-(1',3'-dioxolan)-4'-one (93831-17-5) → cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + sodium phenylphyruvate (114-76-1)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; for 18h; Ambient temperature;

Reference yield: 77.0%

5-benzylidenehydantoin (3775-01-7,74805-60-0,109754-06-5) → sodium phenylphyruvate (114-76-1)

Guidance literature:

With sodium hydroxide; In water; at 140 ℃; for 3h;

Reference yield: 27.0%

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) + sodium pyruvate (113-24-6) → sodium phenylphyruvate (114-76-1) + rac-Ala-OH (302-72-7,25191-17-7,18875-37-1)

Guidance literature:

With acetate buffer; N⁽¹⁺⁾C₅His₂C₁₆; PL⁽¹⁺⁾2C₁₆; copper(II) perchlorate; In water; at 30 ℃; for 48h; Kinetics; var. catalysts;

upstream raw materials:

L-phenylalanine

sodium pyruvate

α-ketoglutaric acid sodium salt

(Z)-5'-benzylidenecyclohexanespiro-2'-(1',3'-dioxolan)-4'-one

Downstream raw materials:

tert-butyl phenylpyruvate

Pd{O₂CC(CH₂C₆H₅)N(CH(CH₃)C₆H₅)}2

2-oxo-3-(phenyl)propionic acid

(C₂₁H₂₄N₄)Fe(C₆H₅CH₂C(O)COO)⁽¹⁺⁾*ClO₄^(1-)=[(C₂₁H₂₄N₄)Fe(C₆H₅CH₂C(O)COO)]ClO₄

Refernces

• 1、 -. "Preparation method of alpha-ketoleucine calcium dihydrate or alpha-ketophenylalanine calcium monohydrate". Paragraph 0065; 0066; 0067; 0075; 0076. . Retrieved 2017/06/02.
• 2、 Murakami, Yukito,Kikuchi, Jun-ichi,Akiyoshi, Kazunari,Imori, Toru. "Functinalised Bilayer Vesicle as a Catalyst for Transamination: Artificial Transaminase". . p. 1919 - 1924. Retrieved 2007/10/02.