Sodium pyruvate, BioXtra, >=99%

Base Information

• Chemical Name: Sodium pyruvate, BioXtra, >=99%
• CAS No.: 113-24-6
• Molecular Formula: C3H3NaO3
• Molecular Weight: 110.045
• Hs Code.: 2918.30 Oral rat LD50: 5,600 mg/kg
• Mol file: 113-24-6.mol

Synonyms:SCHEMBL219526;Sodium pyruvate, p.a., 99%;Sodium pyruvate, BioXtra, >=99%;Sodium pyruvate, purum, >=99.0% (NT);Sodium pyruvate, ReagentPlus(R), >=99%;Sodium pyruvate, SAJ special grade, >=95.0%;Sodium pyruvate, Vetec(TM) reagent grade, 98%;Sodium pyruvate, powder, BioXtra, suitable for mouse embryo;Sodium pyruvate, Hybri-Max(TM), powder, suitable for hybridoma;Sodium pyruvate, anhydrous, free-flowing, Redi-Dri(TM), ReagentPlus(R), >=99%;Sodium pyruvate, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, >=99%

Chemical Property of Sodium pyruvate, BioXtra, >=99%

Chemical Property:

• Appearance/Colour: White to slightly yellow crystalline powder
• Vapor Pressure: 0.968mmHg at 25°C
• Melting Point: >300 °C(lit.)
• Refractive Index: 1,426-1,43
• Boiling Point: 165 °C at 760 mmHg
• Flash Point: 54.3 °C
• PSA: 57.20000
• Density: 1.267 g/cm³
• LogP: -1.67470
• Storage Temp.: 2-8°C
• Solubility.: H2O: 100 mg/mL
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 111.00581327
• Heavy Atom Count: 7
• Complexity: 84

Purity/Quality:

98%min ^*data from raw suppliers

Sodium Pyruvate 99+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/38-36/37/38
• Safety Statements: 37/39-26-24/25-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)C(=O)O.[Na]
• Description: Sodium pyruvate is the sodium salt of pyruvate. It is frequently supplemented to the cell culture medium to act as a source of energy since it is a key intermediate during the production of the high-energy ATP molecules inside cells. For example, it can be used as a carbon source for bacteria. It may also protect cell against hydrogen peroxide, an oxidant to scavenger oxygen radicals. It is an important metabolic intermediate in many essential metabolic pathways such as carbohydrate metabolism. For example, it is converted into acetyl coenzyme A and enters into the TCA cycle (Kreb’s cycle) in organisms. It is also involved in the amino acid metabolism in organisms.
• Uses: Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease Sodium pyruvate is used in cell culture media as an additional source of energy. It acts as an antioxidant and finds protective effects against oxygen radicals. It serves as an intermediate in many metabolic pathways such as sugar metabolism. It is converted into acetyl coenzyme A and enters the trichloroacetic acid cycle. In addition, it is involved with amino acid metabolism and initiates the Kreb's cycle. It plays an important role as a free radical scavenger.
• Biological Functions: Sodium pyruvate (α-Ketopropionic acid sodium salt; 2-Oxopropanoic acid sodium salt；Pyruvic acid sodium; C3H3NaO3) as an important endogenous small molecules participates various tissue and organ metabolism processes that is the final product of glycolysis and the starting substrate for the tricarboxylic acid (TCA) cycle, and possesses antioxidant and scavenging free radical effects, thus widely using as buffer, excipient and antioxidant in medicine, diagnostic reagent and medical device. Sodium pyruvate is an endogenous antioxidant and reactive oxygen radical scavenger. In this process, H2O2 or other reactive oxygen radicals are scavenged by sodium pyruvate by a nonenzymatic reaction or an oxidative dephosphorylation, and produce acetate, water and carbon dioxide. Thus, sodium pyruvate can suppress renal cellular injury induced by H2O2, such as lipid peroxidation of rat kidney homogenate, and cytosolic 51Cr release (a marker of cellular injury) from renal epithelial cells induced by H2O2. Thus, sodium pyruvate as effect antioxidant has potential in the clinical medication. Moreover, as effect antioxidant, sodium pyruvate is also as additives used in a vast range of foods and toiletries.

Technology Process of Sodium pyruvate, BioXtra, >=99%

There total 25 articles about Sodium pyruvate, BioXtra, >=99% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-oxo-propionic acid (127-17-3) → sodium pyruvate (113-24-6)

Guidance literature:

With sodium formate; In ethyl acetate;

Reference yield: 92.0%

poly(methacrylic acid) (79-41-4,25087-26-7,50867-57-7) → sodium pyruvate (113-24-6)

Guidance literature:

poly(methacrylic acid); With ozone; In methanol; dichloromethane; at -78 ℃;

With dimethylsulfide; In methanol; dichloromethane; at -78 - 20 ℃;

With sodium hydroxide; In water;

Reference yield: 55.0%

ethyl 2-hydroxypropionate (97-64-3,2676-33-7) → sodium pyruvate (113-24-6)

Guidance literature:

ethyl 2-hydroxypropionate; With 9-azabicyclo<3.3.1>nonane-N-oxyl; dihydrogen peroxide; In ethyl acetate; at 10 - 40 ℃; for 3h;

With sodium carbonate; In water; ethyl acetate; at 20 ℃; for 1h; pH=3 - 4; Reagent/catalyst; Temperature;

upstream raw materials:

2-oxo-propionic acid

L-alanin

sodium phenylphyruvate

S-allyl cysteine

Downstream raw materials:

L-Tryptophan

(2S,4S,5R,6R)-2,4,5-Trihydroxy-6-((1R,2R)-1,2,3-trihydroxy-propyl)-tetrahydro-pyran-2-carboxylic acid

3-deoxy-D-glycero-D-galacto-nonulosonic acid ammonium salt

3-deoxy-D-glycero-L-altro-nonulosonic acid

Refernces

• 1、 Stoisser, Thomas,Rainer, Daniela,Leitgeb, Stefan,Wilson, David K.,Nidetzky, Bernd. "The Ala95-to-Gly substitution in Aerococcus viridans l -lactate oxidase revisited - Structural consequences at the catalytic site and effect on reactivity with O2 and other electron acceptors". . p. 562 - 578. Retrieved 2015.
• 2、 Wang, Weijun,Baker, Perrin,Seah, Stephen Y. K.. "Comparison of two metal-dependent pyruvate aldolases related by convergent evolution: Substrate specificity, kinetic mechanism, and substrate channeling". . p. 3774 - 3782. Retrieved 2010.
• 3、 Damitio,Smith,Meany,Pocker. "A comparative study of the enolization of pyruvate and the reversible dehydration of pyruvate hydrate". . p. 3081 - 3087. Retrieved 1992.
• 4、 Jun, Chanha,Sa, Young Seung,Gu, Sol-A,Joo, Jeong Chan,Kim, Seil,Kim, Kyung-Jin,Kim, Yong Hwan. "Discovery and characterization of a thermostable D-lactate dehydrogenase from Lactobacillus jensenii through genome mining". . p. 109 - 117. Retrieved 2013/04/10.