4b,6,7,8,8a,10-hexahydrophenanthren-9(5H)-one

Base Information

• Chemical Name: 4b,6,7,8,8a,10-hexahydrophenanthren-9(5H)-one
• CAS No.: 19634-95-8
• Molecular Formula: C₁₄H₁₆O
• Molecular Weight: 200.28
• Mol file: 19634-95-8.mol

Synonyms:NSC254117

Chemical Property of 4b,6,7,8,8a,10-hexahydrophenanthren-9(5H)-one

Chemical Property:

• Vapor Pressure: 8.87E-05mmHg at 25°C
• Boiling Point: 340°Cat760mmHg
• Flash Point: 147.2°C
• Density: 1.084g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4b,6,7,8,8a,10-hexahydrophenanthren-9(5H)-one

There total 5 articles about 4b,6,7,8,8a,10-hexahydrophenanthren-9(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(1-cyclohexenyl)-2-phenylethanone (31142-52-6) → (+/-)-trans-4b,6,7,8,8a,10-hexahydro-5H-phenanthren-9-one (19634-95-8,19634-96-9) + (4bR,8aS)-4b,6,7,8,8a,10-Hexahydro-5H-phenanthren-9-one

Guidance literature:

With boron trifluoride diethyl etherate; In benzene; Irradiation;

DOI:10.1246/bcsj.49.1666

Reference yield:

syn-9.10-Epoxy-1.2.3.4.4a.9.10.10a-(trans-4a.10a)-octahydrophenanthren (28352-34-3) → (+/-)-trans-4b,6,7,8,8a,10-hexahydro-5H-phenanthren-9-one (19634-95-8,19634-96-9) + (4aR,9S,10S,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-phenanthrene-9,10-diol (53446-99-4,646068-56-6) + (4aR,9R,10S,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-phenanthrene-9,10-diol (53446-96-1,646068-56-6)

Guidance literature:

In 1,4-dioxane; water; pH > 7;

DOI:10.1021/ja00371a029

Reference yield:

C14H15(2)HO → (+/-)-trans-4b,6,7,8,8a,10-hexahydro-5H-phenanthren-9-one (19634-95-8,19634-96-9) + C14H17(2)HO2 + C14H17(2)HO2

Guidance literature:

In 1,4-dioxane; water; at 25 ℃; Product distribution; Rate constant; ionic strength 0.1 M (NaClO₄), pH 7.80; hydrolysis of benzylic epoxides, kinetic isotope effect, stereochemical aspects;

DOI:10.1021/ja00371a029

upstream raw materials:

syn-9.10-Epoxy-1.2.3.4.4a.9.10.10a-(trans-4a.10a)-octahydrophenanthren

phenylacetyl chloride

cyclohexene

1-(1-cyclohexenyl)-2-phenylethanone

Refernces

• 1、 Sayer, J. M.,Yagi, H.,Silverton, J. V.,Friedman, S. L.,Whalen, D. L.,Jerina, D. M.. "Conformational Effects in the Hydrolyses of Rigid Benzylic Epoxides: Implications for Diol Epoxides of Polycyclic Hydrocarbons". . p. 1972 - 1978. Retrieved 2007/10/02.