1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione
CAS No.:152814-89-6
Molecular Formula:C19H13 N5 O4
Molecular Weight:375.343
Hs Code.:
UNII:7KKH9V6X32
DSSTox Substance ID:DTXSID70934606
Nikkaji Number:J676.092I
Wikidata:Q27088632
Pharos Ligand ID:3MYKJWY5J5QM
ChEMBL ID:CHEMBL1232082
Mol file:152814-89-6.mol

Synonyms:8-aza-1-(3-nitrophenyl)-3-(4-pyridylmethyl)-2,4-quinazoline-dione;RS 25344;RS-25344

Suppliers and Price of 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
RS 25344 hydrochloride
10mg
$ 423.00

American Custom Chemicals Corporation
RS 25344 HYDROCHLORIDE 95.00%
5MG
$ 459.90

Total 22 raw suppliers

Chemical Property of 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

Chemical Property:

PSA：115.60000
LogP:2.42210
Storage Temp.:Desiccate at RT
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:375.09675391
Heavy Atom Count:28
Complexity:618

Purity/Quality:

99% ^*data from raw suppliers

RS 25344 hydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC(=C1)[N+](=O)[O-])N2C3=C(C=CC=N3)C(=O)N(C2=O)CC4=CC=NC=C4
Uses RS 25344 Hydrochloride is a phosphdiesterase (PDE 4) inhibitor.

Technology Process of 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

There total 6 articles about 1-(3-nitrophenyl)-3-(pyridin-4-ylmethyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1822-51-1
4-picolylchloride hydrochloride

: 56738-76-2
1-(3-nitrophenyl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione

: 152814-89-6
1-(3-nitrophenyl)-3-(4-pyridylmethyl)-1,2,3,4-tetrahydropyrido(2,3-d)pyrimidine-2,4-dione

Guidance literature:: With potassium carbonate; In acetone;

Reference yield:

: 2942-59-8
2-chloronicotinic acid

: 152814-89-6
1-(3-nitrophenyl)-3-(4-pyridylmethyl)-1,2,3,4-tetrahydropyrido(2,3-d)pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol

2: hydrogenchloride / N-methyl-acetamide

3: thionyl chloride / tetrahydrofuran; water; benzene

4: tetrahydrofuran; water

5: potassium carbonate / acetone

With hydrogenchloride; thionyl chloride; potassium carbonate; In tetrahydrofuran; N-methyl-acetamide; ethanol; water; acetone; benzene;

Reference yield:

: 51085-35-9
2-(3-nitroanilino)-3-carbamoylpyridine

: 152814-89-6
1-(3-nitrophenyl)-3-(4-pyridylmethyl)-1,2,3,4-tetrahydropyrido(2,3-d)pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran; water

2: potassium carbonate / acetone

With potassium carbonate; In tetrahydrofuran; water; acetone;