2-((5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)amino)-5-phenyl-4(5H)-thia zolone

Base Information

• Chemical Name: 2-((5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)amino)-5-phenyl-4(5H)-thia zolone
• CAS No.: 199339-13-4
• Molecular Formula: C₁₇H₁₁FN₄O₂S
• Molecular Weight: 354.364
• Mol file: 199339-13-4.mol

Synonyms:

Chemical Property of 2-((5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)amino)-5-phenyl-4(5H)-thia zolone

Chemical Property:

• Vapor Pressure: 3.1E-11mmHg at 25°C
• Boiling Point: 528°Cat760mmHg
• Flash Point: 273.1°C
• PSA: 109.17000
• Density: 1.52g/cm³
• LogP: 3.74340

Purity/Quality:

2-((5-(4-FLUOROPHENYL)-1,3,4-OXADIAZOL-2-YL)AMINO)-5-PHENYL-4(5H)-THIAZOLONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-((5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)amino)-5-phenyl-4(5H)-thia zolone

There total 2 articles about 2-((5-(4-Fluorophenyl)-1,3,4-oxadiazol-2-yl)amino)-5-phenyl-4(5H)-thia zolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

ammonium thiocyanate (1147550-11-5) + 2-Chloro-N-[5-(4-fluoro-phenyl)-[1,3,4]oxadiazol-2-yl]-2-phenyl-acetamide → 2-[(Z)-5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylimino]-5-phenyl-thiazolidin-4-one (199339-13-4)

Guidance literature:

In ethanol; for 1h; Heating;

Reference yield:

2-amino-5-(4-fluorophenyl)-1,3,4-oxadiazole (7659-07-6) → 2-[(Z)-5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylimino]-5-phenyl-thiazolidin-4-one (199339-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / pyridine / benzene / 1 h / Ambient temperature

2: 50 percent / aq. ethanol / 1 h / Heating

With pyridine; In ethanol; benzene;

Reference yield: 60.08%

pyrrolidine (123-75-1) + formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-[(Z)-5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylimino]-5-phenyl-thiazolidin-4-one (199339-13-4) → 2-[(Z)-5-(4-Fluoro-phenyl)-[1,3,4]oxadiazol-2-ylimino]-5-phenyl-5-pyrrolidin-1-ylmethyl-thiazolidin-4-one

Guidance literature:

In ethanol; N,N-dimethyl-formamide; for 4h; Heating;

DOI:10.1002/1521-4184(200102)334:2<35::AID-ARDP35>3.0.CO;2-4

upstream raw materials:

ammonium thiocyanate

2-amino-5-(4-fluorophenyl)-1,3,4-oxadiazole

Downstream raw materials:

5-phenyl-thiazolidine-2,4-dione

2-amino-5-(4-fluorophenyl)-1,3,4-oxadiazole