Tert-butyl pyridin-2-yl carbonate

Base Information

• Chemical Name: Tert-butyl pyridin-2-yl carbonate
• CAS No.: 89985-91-1
• Molecular Formula: C10H13 N O3
• Molecular Weight: 195.218
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID10590927
• Wikidata: Q82484543
• Mol file: 89985-91-1.mol

Synonyms:89985-91-1;tert-butyl pyridin-2-yl carbonate;2-Methyl-2-propanyl 2-pyridinyl carbonate;SCHEMBL8893245;DTXSID10590927

Chemical Property of Tert-butyl pyridin-2-yl carbonate

Chemical Property:

• PSA: 48.42000
• LogP: 2.39550
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 195.08954328
• Heavy Atom Count: 14
• Complexity: 198

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)OC1=CC=CC=N1

Technology Process of Tert-butyl pyridin-2-yl carbonate

There total 9 articles about Tert-butyl pyridin-2-yl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2-hydroxypyridin (142-08-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl pyridin-2-yl carbonate (89985-91-1)

Guidance literature:

2-hydroxypyridin; With dmap; triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃;

DOI:10.1002/anie.201812937

Reference yield: 80.0%

2,2'-dipyridyl carbonate (1659-31-0) + tert-butyl alcohol (75-65-0) → tert-butyl pyridin-2-yl carbonate (89985-91-1)

Guidance literature:

With dmap; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1246/bcsj.58.3570

Reference yield:

2-Pyridone (142-08-5,1199357-22-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl pyridin-2-yl carbonate (89985-91-1)

Guidance literature:

With dmap; In tetrahydrofuran; at 0 ℃; for 10h; Inert atmosphere;

DOI:10.1021/acs.orglett.2c00151

upstream raw materials:

2-hydroxypyridin

phosgene

tert-butyl alcohol

2-pyridone sodium salt

Downstream raw materials:

N-(4-pyridyl) t-butyl carbamate

propylcarbamic acid tert-butyl ester

2-hydroxypyridin

L-N-Boc-Ala