DIMETHYL 2-[2-(4-METHOXYPHENYL)HYDRAZONO]-3-OXOPENTANEDIOATE

Base Information

• Chemical Name: DIMETHYL 2-[2-(4-METHOXYPHENYL)HYDRAZONO]-3-OXOPENTANEDIOATE
• CAS No.: 121582-52-3
• Molecular Formula: C14H16 N2 O6
• Molecular Weight: 308.29
• Hs Code.: 2928000090
• Mol file: 121582-52-3.mol

Synonyms:Pentanedioicacid, 2-[(4-methoxyphenyl)hydrazono]-3-oxo-, dimethyl ester (9CI)

Chemical Property of DIMETHYL 2-[2-(4-METHOXYPHENYL)HYDRAZONO]-3-OXOPENTANEDIOATE

Chemical Property:

• Vapor Pressure: 1.39E-07mmHg at 25°C
• Melting Point: 110-113°
• Boiling Point: 429.5°Cat760mmHg
• Flash Point: 213.6°C
• PSA: 103.29000
• Density: 1.24g/cm³
• LogP: 0.84130

Purity/Quality:

98%min ^*data from raw suppliers

Dimethyl2-[2-(4-methoxyphenyl)hydrazono]-3-oxopentanedioate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of DIMETHYL 2-[2-(4-METHOXYPHENYL)HYDRAZONO]-3-OXOPENTANEDIOATE

There total 2 articles about DIMETHYL 2-[2-(4-METHOXYPHENYL)HYDRAZONO]-3-OXOPENTANEDIOATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3-oxopentanedioic acid dimethyl ester (1830-54-2) + 4-methoxy-aniline (104-94-9) → dimethyl 2-[2-(4-methoxyphenyl)hydrazono]-3-oxopentane-1,5-dioate (121582-52-3)

Guidance literature:

4-methoxy-aniline; With hydrogenchloride; sodium nitrite; In water; at 0 - 5 ℃;

3-oxopentanedioic acid dimethyl ester; With sodium acetate; In ethanol; water; at 0 ℃; for 0.666667h;

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) + 4-methoxy-aniline (104-94-9) → dimethyl 1-(4-methoxyphenyl)hydrazono-2-oxopropane-1,3-dicarboxylate (121582-52-3)

Guidance literature:

With hydrogenchloride; sodium acetate; sodium nitrite; Yield given. Multistep reaction; 1.) water, below 5 deg C, 2.) ethanol, water, 30 min;

Reference yield: 95.0%

dimethyl 1-(4-methoxyphenyl)hydrazono-2-oxopropane-1,3-dicarboxylate (121582-52-3) → 2-(4-methoxyphenyl)-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylic acid (121582-69-2)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

3-oxopentanedioic acid dimethyl ester

4-methoxy-aniline

Downstream raw materials:

2-(4-methoxyphenyl)-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylic acid

4-hydroxy-6-oxo-1-(4-methoxyphenyl)-1,6-dihydropyridazin-3-carboxylic acid methyl ester

5-hydroxy-2-(4-hydroxyphenyl)-3-oxo-2,3-dihydropyridazine-6-carboxylic acid

dimethyl 1-(4-methoxyphenyl)-4-oxo-1,4-dihydropyridazine-3,5-dicarboxylate

Refernces

• 1、 Schober, Bernt D.,Megyeri, Gabor,Kappe, Thomas. "Pyridazines with Heteroatom Substituents in Position 3 and 5. 3) 2-Aryl-5-hydroxypyridazin-3(2H)-ones as Potential Herbicides: Synthesis and Some Reactions". . p. 169 - 176. Retrieved 2007/10/02.