METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

Base Information

• Chemical Name: METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE
• CAS No.: 121582-61-4
• Molecular Formula: C13H12 N2 O5
• Molecular Weight: 276.24
• Hs Code.: 2933990090
• Mol file: 121582-61-4.mol

Synonyms:METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE;AURORA KA-3618

Chemical Property of METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 184-186°C
• Boiling Point: 438.2°Cat760mmHg
• Flash Point: 218.8°C
• PSA: 90.65000
• Density: 1.35g/cm³
• LogP: 0.73330
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl 4-hydroxy-1-(4-methoxyphenyl)-6-oxo-1,6-dihydro-3-pyridazinecarboxylate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE

There total 3 articles about METHYL 4-HYDROXY-1-(4-METHOXYPHENYL)-6-OXO-1,6-DIHYDRO-3-PYRIDAZINECARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

dimethyl 1-(4-methoxyphenyl)hydrazono-2-oxopropane-1,3-dicarboxylate (121582-52-3) → 4-hydroxy-6-oxo-1-(4-methoxyphenyl)-1,6-dihydropyridazin-3-carboxylic acid methyl ester (121582-61-4)

Guidance literature:

In 1,2-dichloro-benzene; for 0.75h; Heating;

Reference yield:

3-oxopentanedioic acid dimethyl ester (1830-54-2) → 4-hydroxy-6-oxo-1-(4-methoxyphenyl)-1,6-dihydropyridazin-3-carboxylic acid methyl ester (121582-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. HCl, NaNO₂, 2.) sodium acetate / 1.) water, below 5 deg C, 2.) ethanol, water, 30 min

2: 82 percent / 1,2-dichloro-benzene / 0.75 h / Heating

With hydrogenchloride; sodium acetate; sodium nitrite; In 1,2-dichloro-benzene;

Reference yield:

4-methoxy-aniline (104-94-9) → 4-hydroxy-6-oxo-1-(4-methoxyphenyl)-1,6-dihydropyridazin-3-carboxylic acid methyl ester (121582-61-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) conc. HCl, NaNO₂, 2.) sodium acetate / 1.) water, below 5 deg C, 2.) ethanol, water, 30 min

2: 82 percent / 1,2-dichloro-benzene / 0.75 h / Heating

With hydrogenchloride; sodium acetate; sodium nitrite; In 1,2-dichloro-benzene;

upstream raw materials:

dimethyl 1-(4-methoxyphenyl)hydrazono-2-oxopropane-1,3-dicarboxylate

3-oxopentanedioic acid dimethyl ester

4-methoxy-aniline

Downstream raw materials:

5-hydroxy-2-(4-hydroxyphenyl)-3-oxo-2,3-dihydropyridazine-6-carboxylic acid

2-(4-methoxyphenyl)-5-hydroxy-3-oxo-2,3-dihydropyridazine-6-carboxylic acid

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