2-pyrrol-1-ylacetic acid

Base Information

• Chemical Name: 2-pyrrol-1-ylacetic acid
• CAS No.: 19167-98-7
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.1253
• Hs Code.: 2933990090
• Mol file: 19167-98-7.mol

Synonyms:Pyrrole-1-aceticacid (8CI);2-(1-Pyrrolyl)acetic acid;NSC 50134;

Chemical Property of 2-pyrrol-1-ylacetic acid

Chemical Property:

• Vapor Pressure: 0.00316mmHg at 25°C
• Refractive Index: 1.542
• Boiling Point: 271.4 °C at 760 mmHg
• Flash Point: 118 °C
• PSA: 42.23000
• Density: 1.18 g/cm³
• LogP: 0.57270
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

1H-Pyrrol-1-ylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-pyrrol-1-ylacetic acid

There total 7 articles about 2-pyrrol-1-ylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-ethoxycarbonylmethyl-1H-pyrrole (5145-67-5) → pyrrol-1-yl-acetic acid (19167-98-7)

Guidance literature:

With potassium hydroxide; In methanol; at 20 ℃; for 12h;

DOI:10.1002/hlca.19830660835

Reference yield: 64.0%

cis,trans-2,5-dimethoxytetrahydrofuran (696-59-3) + glycine (56-40-6,18875-39-3,25718-94-9) → pyrrol-1-yl-acetic acid (19167-98-7)

Guidance literature:

In acetic acid; at 80 ℃; for 0.5h;

Reference yield: 64.0%

pyrrole-1-yl-acetic acid methyl ester (50966-72-8) → pyrrol-1-yl-acetic acid (19167-98-7)

Guidance literature:

upstream raw materials:

1-ethoxycarbonylmethyl-1H-pyrrole

pyrrole-1-yl-acetic acid methyl ester

1,4-dichloro-1,4-dimethoxybutane

glycine

Refernces

• 1、 Unsworth, William P.,Coulthard, Graeme,Kitsiou, Christiana,Taylor, Richard J. K.. "Direct imine acylation for molecular diversity in heterocyclic synthesis". . p. 1368 - 1376. Retrieved 2014/03/21.
• 2、 Shmatova, Olga I.,Shevchenko, Nikolay E.,Balenkova, Elizabeth S.,R?schenthaler, Gerd-Volker,Nenajdenko, Valentine G.. "Friedel-Crafts alkylation of natural amino acid-derived pyrroles with CF3-substituted cyclic imines". . p. 92 - 93. Retrieved 2013/05/09.