4-(Chloroethoxy)aniline

Base Information

• Chemical Name: 4-(Chloroethoxy)aniline
• CAS No.: 27692-35-9
• Molecular Formula: C8H10 Cl N O
• Molecular Weight: 171.626
• Hs Code.: 2922299090
• European Community (EC) Number: 248-609-2
• DSSTox Substance ID: DTXSID40182051
• Nikkaji Number: J250.573H
• Mol file: 27692-35-9.mol

Synonyms:4-(2-chloroethoxy)aniline;27692-35-9;4-(Chloroethoxy)aniline;EINECS 248-609-2;Benzenamine, 4-(2-chloroethoxy)-;4-(2-chloroethoxy)-aniline;4-(2'-chloroethoxy)-aniline;SCHEMBL1735207;4-(2-chloro-ethoxy)-phenylamine;DTXSID40182051;CBA69235;AKOS006302416;AM806233

Chemical Property of 4-(Chloroethoxy)aniline

Chemical Property:

• Vapor Pressure: 0.00117mmHg at 25°C
• Boiling Point: 299.8°Cat760mmHg
• Flash Point: 135.1°C
• PSA: 35.25000
• Density: 1.195g/cm³
• LogP: 2.46760
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 171.0450916
• Heavy Atom Count: 11
• Complexity: 102

Purity/Quality:

99% ^*data from raw suppliers

4-(2-Chloroethoxy)aniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1N)OCCCl

Technology Process of 4-(Chloroethoxy)aniline

There total 7 articles about 4-(Chloroethoxy)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(2-chloroethoxy)-4-nitrobenzene (3383-72-0) → 4-(2'-chloroethoxy)-aniline (27692-35-9)

Guidance literature:

With tin(ll) chloride; In ethanol; water; at 70 ℃; for 2h;

Reference yield:

2-[4-(acetylamino)phenoxy]ethanol (50375-15-0) → 4-(2'-chloroethoxy)-aniline (27692-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / CHCl₃; dimethylformamide / 2.5 h / Heating

2: 10.1 g / aq. HCl / 0.5 h / Heating

With hydrogenchloride; thionyl chloride; In chloroform; N,N-dimethyl-formamide;

DOI:10.1016/S0223-5234(01)01246-6

Reference yield:

2-(4-acetamidophenoxy)ethyl chloride (36616-28-1) → 4-(2'-chloroethoxy)-aniline (27692-35-9)

Guidance literature:

With hydrogenchloride; for 3.5h; Heating;

upstream raw materials:

2-(4-acetamidophenoxy)ethyl chloride

4-acetaminophenol

2-[4-(acetylamino)phenoxy]ethanol

1-(2-chloroethoxy)-4-nitrobenzene

Downstream raw materials:

2-amino-N-[4-(2-chloro-ethoxy)-phenyl]-4-methoxy-benzamide

2-amino-N-[4-(2-chloro-ethoxy)-phenyl]-3-methoxy-benzamide

4-[2-(3-benzyl-3,8-diaza-bicyclo[3.2.1]oct-8-yl)-ethoxy]-phenylamine

C₁₁H₁₅ClN₂O₃