N-(4-(2-Chloroethoxy)phenyl)acetamide

Base Information

• Chemical Name: N-(4-(2-Chloroethoxy)phenyl)acetamide
• CAS No.: 36616-28-1
• Molecular Formula: C10H12ClNO2
• Molecular Weight: 213.664
• European Community (EC) Number: 253-127-0
• DSSTox Substance ID: DTXSID00190091
• Nikkaji Number: J332.324B
• Wikidata: Q83062362
• Mol file: 36616-28-1.mol

Synonyms:N-(4-(2-Chloroethoxy)phenyl)acetamide;N-[4-(2-chloroethoxy)phenyl]acetamide;36616-28-1;EINECS 253-127-0;N-[4-(2-CHLORO-ETHOXY)-PHENYL]-ACETAMIDE;2-(4-acetamidophenoxy)ethyl chloride;SCHEMBL8347010;DTXSID00190091;HLLURZQGVBWFRD-UHFFFAOYSA-N;Acetamide, N-(4-(2-chloroethoxy)phenyl)-

Chemical Property of N-(4-(2-Chloroethoxy)phenyl)acetamide

Chemical Property:

• Vapor Pressure: 9.88E-07mmHg at 25°C
• Boiling Point: 403.8°Cat760mmHg
• Flash Point: 198°C
• Density: 1.225g/cm³
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 213.0556563
• Heavy Atom Count: 14
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=C(C=C1)OCCCl

Technology Process of N-(4-(2-Chloroethoxy)phenyl)acetamide

There total 9 articles about N-(4-(2-Chloroethoxy)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(2-chloroethoxy)-4-nitrobenzene (3383-72-0) + acetic anhydride (108-24-7) → 2-(4-acetamidophenoxy)ethyl chloride (36616-28-1)

Guidance literature:

With acetic acid; zinc; at 80 ℃; for 6h;

DOI:10.1016/j.ejmech.2004.10.006

Reference yield: 43.0%

4-acetaminophenol (103-90-2,8055-08-1) + 1-Bromo-2-chloroethane (107-04-0) → 2-(4-acetamidophenoxy)ethyl chloride (36616-28-1)

Guidance literature:

With potassium hydroxide; In ethanol; at 85 ℃; for 5h;

Reference yield:

2-chloroethyl-p-toluene sulfonate + 4-acetaminophenol (103-90-2,8055-08-1) → 2-(4-acetamidophenoxy)ethyl chloride (36616-28-1)

Guidance literature:

With potassium hydroxide; In ethyl acetate; acetone;

upstream raw materials:

2-chloroethyl tosylate

4-acetaminophenol

2-chloroethyl benzenesulfonate

2-[4-(acetylamino)phenoxy]ethanol

Downstream raw materials:

1-[2-(4-acetylamino-phenoxy)-ethyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester

acetic acid-[4-(2-diethylamino-ethoxy)-anilide]

N-[4-(2-chloroethoxy)-2-nitrophenyl]acetamide

4-(2-(piperidin-1-yl)ethoxy)aniline

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