N-(diphenylmethyl)glycine

Base Information

• Chemical Name: N-(diphenylmethyl)glycine
• CAS No.: 40718-29-4
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Hs Code.: 2922499990
• Mol file: 40718-29-4.mol

Synonyms:Cbz-L-Pro-L-Leu methyl ester;Z-Pro-Leu-OMe;Z-Pro-Leu-OCH3;N-benzhydryl-glycine;N-Cbz-L-Pro-L-Leu-OMe;N-Benzhydrylaminoessigsaeure;Cbz-L-proline-L-leucine methyl ester;Benzyloxycarbonyl-L-prolyl-leucine methyl ester;

Chemical Property of N-(diphenylmethyl)glycine

Chemical Property:

• Vapor Pressure: 3.99E-07mmHg at 25°C
• Boiling Point: 400.3°Cat760mmHg
• Flash Point: 195.9°C
• PSA: 49.33000
• Density: 1.171g/cm³
• LogP: 2.84110

Purity/Quality:

99% ^*data from raw suppliers

2-[(DIPHENYLMETHYL)AMINO]ACETIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(diphenylmethyl)glycine

There total 4 articles about N-(diphenylmethyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(benzhydrylamino)acetic acid ethyl ester (40718-32-9) → [N-(diphenylmethyl)amino]acetic acid (40718-29-4)

Guidance literature:

2-(benzhydrylamino)acetic acid ethyl ester; With methanol; potassium hydroxide; for 2h; Heating / reflux;

With hydrogenchloride; water; pH=7.3;

Reference yield:

benzophenone (119-61-9) + glycine (56-40-6,18875-39-3,25718-94-9) → [N-(diphenylmethyl)amino]acetic acid (40718-29-4)

Guidance literature:

With sodium cyanoborohydride; In methanol; water; for 18h; Heating;

DOI:10.1021/jm00072a019

Reference yield:

Benzhydrylamine (91-00-9) → [N-(diphenylmethyl)amino]acetic acid (40718-29-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 60 °C

2.1: methanol; lithium hydroxide; water / tetrahydrofuran / 20 °C

2.2: pH 3

With methanol; lithium hydroxide; water; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

benzophenone

glycine

2-(benzhydrylamino)acetic acid ethyl ester

Benzhydrylamine

Downstream raw materials:

{1-[2-(Benzhydryl-amino)-acetyl]-piperidin-4-yl}-pyridin-3-yl-acetonitrile

{4-[2-(Benzhydryl-amino)-acetyl]-piperazin-1-yl}-pyridin-3-yl-acetonitrile

2-(benzhydryl-amino)-N-(3,3-diphenyl-propyl)-acetamide hydrochloride

Refernces

SYNTHESIS AND PSYCHOPHARMACOLOGICAL ACTIVITY OF BENZHYDRYL GLYCINE DERIVATIVES

10.1007/BF00758310

The study investigates the synthesis and psychopharmacological activity of benzhydrylglycine derivatives (compounds I-VI) to explore their structure-activity relationship. The chemicals involved include methyl N-(2-oxy-5-bromobenzhydryl)glycine (I), N-(2-oxy-5-bromobenzhydryl)glycine (II), methyl N-(2-chloro-5-bromobenzhydryl)glycine (III), ammonium oxide N-(2-amino-5-bromobenzhydryl)glycine (IV), methyl N-(2-acetamido-5-bromobenzhydryl)glycine (V), and methyl N-[2-(o-chlorobenzamido)-5-bromobenzhydryl]glycine (VI). These compounds were synthesized and tested for their antiamnesia activity and effects on various reflexes and muscle tone in rodents. The study found that the antiamnesia activity of these compounds depends on the substituents R and R' on the benzhydryl fragment and glycine residue, with compounds V and VI showing higher activity.

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