3-[(propan-2-yloxy)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

Base Information

• Chemical Name: 3-[(propan-2-yloxy)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid
• CAS No.: 29745-06-0
• Molecular Formula: C11H16 O5
• Molecular Weight: 228.245
• Mol file: 29745-06-0.mol

Synonyms:7-Oxabicyclo[2.2.1]heptane-2,3-dicarboxylicacid, monoisopropyl ester, cis-exo- (8CI); Monoisopropyl7-oxabicyclo)2.2.1]heptane-exocis-2,3-dicarboxylate

Chemical Property of 3-[(propan-2-yloxy)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 5.45E-06mmHg at 25°C
• Boiling Point: 354.8°Cat760mmHg
• Flash Point: 135.9°C
• Density: 1.271g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(propan-2-yloxy)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid

There total 3 articles about 3-[(propan-2-yloxy)carbonyl]-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride (6118-51-0) → (+/-)-7-Oxa-bicyclo[2.2.1]heptan-exo-cis-dicarbonsaeure-monoisopropylester; (+/-)-Oxa-norbornan-2-exo,3-exo-dicarbonsaeure-2-isopropylester (29745-06-0)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd / ethyl acetate

2: tetrahydrofuran / Ambient temperature

With hydrogen; palladium; In tetrahydrofuran; ethyl acetate;

DOI:10.1021/jo971731t

Reference yield:

titanium(IV)isopropoxide (546-68-9) + norcantharidin (29745-04-8) → (+/-)-7-Oxa-bicyclo[2.2.1]heptan-exo-cis-dicarbonsaeure-monoisopropylester; (+/-)-Oxa-norbornan-2-exo,3-exo-dicarbonsaeure-2-isopropylester (29745-06-0)

Guidance literature:

In tetrahydrofuran; Ambient temperature;

DOI:10.1021/jo971731t

Reference yield:

→ (+/-)-7-Oxa-bicyclo[2.2.1]heptan-exo-cis-dicarbonsaeure-monoisopropylester; (+/-)-Oxa-norbornan-2-exo,3-exo-dicarbonsaeure-2-isopropylester (29745-06-0)

Guidance literature:

DOI:10.1021/jm00284a027

upstream raw materials:

titanium(IV)isopropoxide

norcantharidin

exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride