Technology Process of 7-{[8-{[(1aS,9bR)-5-oxo-1a,2-dihydro-1H-benzo[e]cyclopropa[c]indol-3(5H)-yl]carbonyl}-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl}-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carboxamide
There total 18 articles about 7-{[8-{[(1aS,9bR)-5-oxo-1a,2-dihydro-1H-benzo[e]cyclopropa[c]indol-3(5H)-yl]carbonyl}-1,6-dihydropyrrolo[3,2-e]indol-3(2H)-yl]carbonyl}-1,6-dihydropyrrolo[3,2-e]indole-3(2H)-carboxamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
at 0 ℃;
for 1h;
DOI:10.1021/ja00198a089
- Guidance literature:
-
Multi-step reaction with 11 steps
2: 96 percent / dioxane / 3 h / 95 °C
3: 98 percent / N-bromosuccinimide, H2SO4 / tetrahydrofuran / 5 h / -60 °C
4: 100 percent / NaH / 3 h / 24 °C
5: Bu3SnH, AIBN / benzene / 1 h / 80 °C
6: 1.) Me2S*BH3, 2.) 2 N aq. NaOH, 30percent aq. H2O2 / 1.) THF, 0-25 deg C, 3 h, 2.) 0-25 deg C, 1 h; 45 deg C, 20 min
7: 99 percent / Ph3P, CCl4 / CH2Cl2 / 10 h / 24 °C
8: 97 percent / 25percent aq. HCO2NH4 / 10percent Pd/C / tetrahydrofuran / 2.5 h / 0 °C
9: 100 percent / 3 N HCl / ethyl acetate / 0.17 h / 24 °C
10: 78 percent / 1-<(3-dimethylamino)propyl>-3-ethylcarbodiimide, NaHCO3 / dimethylformamide / 5 h / 24 °C
11: 84 percent / NaH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C
With
hydrogenchloride; tetrachloromethane; sodium hydroxide; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); dimethylsulfide borane complex; sulfuric acid; dihydrogen peroxide; tri-n-butyl-tin hydride; ammonium formate; sodium hydride; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00198a089
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / Ph3P, CCl4 / CH2Cl2 / 10 h / 24 °C
2: 97 percent / 25percent aq. HCO2NH4 / 10percent Pd/C / tetrahydrofuran / 2.5 h / 0 °C
3: 100 percent / 3 N HCl / ethyl acetate / 0.17 h / 24 °C
4: 78 percent / 1-<(3-dimethylamino)propyl>-3-ethylcarbodiimide, NaHCO3 / dimethylformamide / 5 h / 24 °C
5: 84 percent / NaH / tetrahydrofuran; dimethylformamide / 1 h / 0 °C
With
hydrogenchloride; tetrachloromethane; ammonium formate; sodium hydride; sodium hydrogencarbonate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/ja00198a089