122745-39-5

Basic information

• Product Name: 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole
• Synonyms: 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole
• CAS NO: 122745-39-5
• Molecular Weight: 405.494
• Mol File: 122745-39-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole(122745-39-5)
• EPA Substance Registry System: 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole(122745-39-5)

Safety Data

• Hazardous Substances Data: 122745-39-5(Hazardous Substances Data)

Upstream product

• 161646-54-4 2-<amino>-4-(benzyloxy)-1-iodonaphthalene 
• 100-39-0 benzyl bromide 
• 129918-06-5 2--4-(benzyloxy)-1-bromonaphthalene 
• 129918-05-4 2--4-(benzyloxy)-1-bromonaphthalene 
• 139976-01-5 5-(Benzyloxy)-3-(tert-butyloxycarbonyl)-1-<(tetrahydropyranyloxy)methyl>-1,2-dihydro-3H-benzindole 
• 501440-80-8 3-(N-tert-butyloxycarbonyl)amino-1-O-(tertbutyloxycarbonyl)-1-naphthol 
• 2764-95-6 4-methoxy-2-naphthylamine 
• 19256-80-5 3-Nitro-1-naphthol 
• 139975-99-8 2-amino>-4-(benzyloxy)-1-bromonaphthalene 
• 139975-98-7 tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate 
• 132-86-5 1,3-dihydroxynaphthalene 
• 122745-45-3 N-(tert-butyloxycarbonyl)-N-(2-propynyl)-4-(benzyloxy)-1-bromo-2-naphthylamine 
• 122745-37-3 2-((tert-Butyloxycarbonyl)amino)-4-(benzyloxy)-1-bromonaphthalene 
• 122745-35-1 3-Amino-1-(benzyloxy)naphthalene 

Downstream Products

• 128228-76-2 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole, (R)-(-)-O-acetylmandelate ester 
• 128228-77-3 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole, (R)-(-)-O-acetyl mandelate ester 
• 128300-10-7 (-)-(1R)-5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 
• 685142-95-4 (S)-1-(acetoxymethyl)-5-benzyloxy-3-(tert-butyloxycarbonyl)-2,3-dihydro-1H-benz[e]indole 
• 244154-66-3 tert-butyl (S)-1-(chloromethyl)-5-((4-methylpiperazine-1-carbonyl)oxy)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 128300-15-2 (+)-CBI-CDPI2 
• 122745-34-0 (+/-)-CBI-CDPI2 
• 128300-11-8 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole 
• 128300-09-4 (+)-(1S)-5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzindole 
• 122745-41-9 tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 122745-40-8 tert-Butyl(S)-5-(benzyloxy)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 128300-12-9 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole 
• 130008-89-8 3-(tert-butyloxycarbonyl)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzindole 

Relevant articles and documents

ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS

Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.

An Improved Synthesis of 1,2,9,9a-Tetrahydrocyclopropabenzindol-4-one (CBI): A Simplified Analogue of the CC-1065 Alkylation Subunit

A concise and improved synthesis of 11, the immediate precursor to N-BOC-CBI and related analogues of CC-1065 incorporating the 1,2,9,9a-tetrahydrocyclopropabenzindol-4-one alkylation subunit, is detailed based on a direct 5-exo-trig aryl radical-al

Total Synthesis and Evaluation of (+/-)-N-(tert-Butyloxycarbonyl)-CBI, (+/-)-CBI-CDPI1, and (+/-)-CBI-CDPI2: CC-1065 Functional Agents Incorporating the Equivalent 1,2,9,9a-Tetrahydrocyclopropbenzindol-4-one (CBI) Left-Hand Subunit

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