5,7-Dimethyl-1,8-naphthyridin-2(1H)-one

Base Information

• Chemical Name: 5,7-Dimethyl-1,8-naphthyridin-2(1H)-one
• CAS No.: 51420-71-4
• Molecular Formula: C10H10 N2 O
• Molecular Weight: 174.202
• European Community (EC) Number: 257-195-2
• NSC Number: 114907
• DSSTox Substance ID: DTXSID00199408
• Nikkaji Number: J261.718H
• Mol file: 51420-71-4.mol

Synonyms:51420-71-4;5,7-Dimethyl-1,8-naphthyridin-2(1H)-one;5,7-dimethyl-1,8-naphthyridin-2-ol;5,7-dimethyl-1H-1,8-naphthyridin-2-one;EINECS 257-195-2;5,7-Dimethyl-1,8-naphthyridine-2-ol;1,8-Naphthyridin-2(1H)-one, 5,7-dimethyl-;NSC114907;Oprea1_522637;SCHEMBL3320128;DTXSID00199408;MFCD00066907;STK664677;5,7-dimethyl[1,8]naphthyridin-2-ol;AKOS002664357;5,7-dimethyl-1,8-naphthyridin-2-one;NSC 114907;NSC-114907;5,7-Dimethyl-[1,8]naphthyridin-2-ol;LS-08461;CS-0331917;FT-0755722;F83681;5,7-dimethyl-1,2-dihydro-1,8-naphthyridin-2-one

Chemical Property of 5,7-Dimethyl-1,8-naphthyridin-2(1H)-one

Chemical Property:

• Vapor Pressure: 6.76E-06mmHg at 25°C
• Boiling Point: 377.4°C at 760 mmHg
• Flash Point: 182.1°C
• Density: 1.178g/cm³
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 249

Purity/Quality:

99% ^*data from raw suppliers

5,7-Dimethyl-1,8-naphthyridin-2-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC2=C1C=CC(=O)N2)C

Technology Process of 5,7-Dimethyl-1,8-naphthyridin-2(1H)-one

There total 6 articles about 5,7-Dimethyl-1,8-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

7-amino-2,4-dimethyl-1,8-naphthyridine (39565-07-6) → 2-hydroxyl-5,7-dimethyl-1,8-naphthyridine (51420-71-4)

Guidance literature:

With sulfuric acid; sodium nitrite; for 0.25h;

DOI:10.1016/S0022-328X(00)82948-4

Reference yield: 85.0%

7-amino-2,4-dimethyl-1,8-naphthyridine (39565-07-6) → 5,7-dimethyl-1,8-naphthyridin-2(1H)-one (51420-71-4)

Guidance literature:

With sulfuric acid; sodium nitrite; at 20 ℃; for 0.0833333h;

DOI:10.1134/S1070363218090050

Reference yield:

acetylacetone (123-54-6,81235-32-7) → 5,7-dimethyl-1,8-naphthyridin-2(1H)-one (51420-71-4)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated H₂SO₄

2: H₂O / Diazotization

With sulfuric acid; water;

upstream raw materials:

7-amino-2,4-dimethyl-1,8-naphthyridine

2.6-diaminopyridine

acetylacetone

Downstream raw materials:

7-chloro-2,4-dimethyl-1,8-naphthyridine

4-<(2-oxo-2-phenyl)ethyl>-7-hydroxy-2-methyl-1,8-naphthyridine

2-<(2-oxo-2-phenyl)ethyl>-7-hydroxy-4-methyl-1,8-naphthyridine

5,7-dimethyl-1,2,3,4-tetrahydro[1,8]naphthyridine

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