2,4-DIMETHYL-[1,8]NAPHTHYRIDINE

Base Information

• Chemical Name: 2,4-DIMETHYL-[1,8]NAPHTHYRIDINE
• CAS No.: 7544-64-1
• Molecular Formula: C10H10N2
• Molecular Weight: 158.2
• Hs Code.: 2933990090
• Mol file: 7544-64-1.mol

Synonyms:2,4-DIMETHYL-[1,8]NAPHTHYRIDINE

Chemical Property of 2,4-DIMETHYL-[1,8]NAPHTHYRIDINE

Chemical Property:

• PSA: 25.78000
• LogP: 2.24660

Purity/Quality:

97% ^*data from raw suppliers

2,4-dimethyl-1,8-naphthyridine 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-DIMETHYL-[1,8]NAPHTHYRIDINE

There total 6 articles about 2,4-DIMETHYL-[1,8]NAPHTHYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2-Amino-4,6-dimethylpyridine (5407-87-4) + glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2,4-dimethyl[1,8]naphthyridine (7544-64-1)

Guidance literature:

With NO₂PhSO₃Na; sulfuric acid; boric acid; iron(II) sulfate; at 150 ℃; for 4h;

DOI:10.1055/s-2005-865308

Reference yield:

2-Amino-4,6-dimethylpyridine (5407-87-4) + acrolein (107-02-8,25068-14-8) → 2,4-dimethyl[1,8]naphthyridine (7544-64-1)

Guidance literature:

2-Amino-4,6-dimethylpyridine; With hydrogenchloride; iodine; acetic acid; In water; at 95 - 100 ℃;

acrolein; In water; for 8h;

Reference yield:

7-chloro-2,4-dimethyl-1,8-naphthyridine (77223-21-3) → 2,4-dimethyl[1,8]naphthyridine (7544-64-1)

Guidance literature:

With potassium hydroxide; palladium on activated charcoal; Lindlar's catalyst; Hydrogenation;

upstream raw materials:

7-chloro-2,4-dimethyl-1,8-naphthyridine

2-Amino-4,6-dimethylpyridine

glycerol

7-amino-2,4-dimethyl-1,8-naphthyridine

Downstream raw materials:

6-bromo-5,7-dimethyl-1,2,3,4-tetrahydro[1,8]naphthyridine

5,7-dimethyl-1,2,3,4-tetrahydro[1,8]naphthyridine

Refernces

• 1、 -. "Method for preparing 1,8-naphthyridine and derivatives". Paragraph 0035-0037. . Retrieved 2018/02/04.