Ethyl 2,6-dibromopyridine-4-carboxylate

Base Information

• Chemical Name: Ethyl 2,6-dibromopyridine-4-carboxylate
• CAS No.: 90050-70-7
• Molecular Formula: C8H7 Br2 N O2
• Molecular Weight: 308.957
• Hs Code.: 2933399090
• Mol file: 90050-70-7.mol

Synonyms:Isonicotinicacid, 2,6-dibromo-, ethyl ester (7CI); Ethyl 2,6-dibromo-4-pyridinecarboxylate;Ethyl 2,6-dibromoisonicotinate

Chemical Property of Ethyl 2,6-dibromopyridine-4-carboxylate

Chemical Property:

• Vapor Pressure: 0.000136mmHg at 25°C
• Boiling Point: 333.5°Cat760mmHg
• Flash Point: 155.5°C
• PSA: 39.19000
• Density: 1.823g/cm³
• LogP: 2.78330

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2,6-dibromoisonicotinate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2,6-dibromopyridine-4-carboxylate

There total 4 articles about Ethyl 2,6-dibromopyridine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethanol (64-17-5) + 2,6-dibromoisonicotinic acid (2016-99-1) → ethyl 2,6-dibromo-pyridine-4-carboxylate (90050-70-7)

Guidance literature:

With sulfuric acid; for 15h; Heating;

DOI:10.1016/j.tet.2006.10.051

Reference yield: 50.4%

ethanol (64-17-5) + citrazinic acid (99-11-6) → ethyl 2,6-dibromo-pyridine-4-carboxylate (90050-70-7)

Guidance literature:

citrazinic acid; With phosphorus(V) oxybromide; at 185 ℃; for 2h; Inert atmosphere;

ethanol; at 60 - 70 ℃; for 0.5h;

DOI:10.1021/jacs.7b05458

Reference yield:

citrazinic acid (99-11-6) → ethyl 2,6-dibromo-pyridine-4-carboxylate (90050-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / POBr₃ / 3 h / 130 °C

2: 93 percent / H₂SO₄ / 15 h / Heating

With sulfuric acid; phosphorus(V) oxybromide;

DOI:10.1016/j.tet.2006.10.051

upstream raw materials:

ethanol

2,6-dibromoisonicotinic acid

citrazinic acid

Downstream raw materials:

6-Bromo-2,2'-bipyridine-4-carboxylic acid

Ethyl 6-bromo-2,2'-bipyridine-4-carboxylate

[2,2′:6′,2′′-terpyridine]-4′-carboxylic acid

4’-ethoxycarbonyl-2,2’:6’,2’’-terpyridine