19-Oxo-11-deoxycorticosterone acetate

Base Information

Chemical Name:19-Oxo-11-deoxycorticosterone acetate
CAS No.:88378-35-2
Molecular Formula:C₂₃H₃₀O₅
Molecular Weight:386.488
Hs Code.:
DSSTox Substance ID:DTXSID701008107
Wikidata:Q83004459
Mol file:88378-35-2.mol

Synonyms:19-oxo-11-deoxycorticosterone acetate;19-oxo-DOCA

Suppliers and Price of 19-Oxo-11-deoxycorticosterone acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 19-Oxo-11-deoxycorticosterone acetate

Chemical Property:

Vapor Pressure:1.17E-11mmHg at 25°C
Boiling Point:538.3°C at 760 mmHg
Flash Point:233.4°C
PSA：77.51000
Density:1.2g/cm³
LogP:3.44570
XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:386.20932405
Heavy Atom Count:28
Complexity:752

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C=O)C
Isomeric SMILES:CC(=O)OCC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C=O)C

Technology Process of 19-Oxo-11-deoxycorticosterone acetate

There total 25 articles about 19-Oxo-11-deoxycorticosterone acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.6%

: 6901-40-2
19,21-dihydroxypregn-4-ene-3,20-dione 21-acetate

: 88378-35-2
19-oxo-11-deoxycorticosterone acetate

Guidance literature:: With chromium(VI) oxide; In pyridine; water; at 60 ℃; for 1.5h;
DOI:10.1016/S0040-4020(01)87452-4

Reference yield:

: 1778-02-5
Pregnenolone acetate

: 88378-35-2
19-oxo-11-deoxycorticosterone acetate

Guidance literature:: Multi-step reaction with 8 steps

1: hypobromous acid

2: Pb(OAc)4, I₂ / Irradiation

3: hydrolysis

4: 1.) BF₃*Et₂O / 1.) C₆H₆, MeOH, room temperature, 20 min, 2.) 5 h

5: Jones reagent / acetone / 5 °C

6: NaOAc / methanol / 1 h / Heating

7: 111 mg / Zn, AcOH / propan-2-ol / 3 h / Heating

8: 55 mg / pyridinuim chlorochromate / CH₂Cl₂ / 0.5 h / Ambient temperature

With lead(IV) acetate; jones reagent; boron trifluoride diethyl etherate; iodine; sodium acetate; hypobromous acid; acetic acid; pyridinium chlorochromate; zinc; In methanol; dichloromethane; isopropyl alcohol; acetone;

Reference yield:

: 2723-07-1
5-Bromo-6β-hydroxy-20-oxo-5α-pregnan-3β-yl acetate

: 88378-35-2
19-oxo-11-deoxycorticosterone acetate

Guidance literature:: Multi-step reaction with 7 steps

1: Pb(OAc)4, I₂ / Irradiation

2: hydrolysis

3: 1.) BF₃*Et₂O / 1.) C₆H₆, MeOH, room temperature, 20 min, 2.) 5 h

4: Jones reagent / acetone / 5 °C

5: NaOAc / methanol / 1 h / Heating

6: 111 mg / Zn, AcOH / propan-2-ol / 3 h / Heating

7: 55 mg / pyridinuim chlorochromate / CH₂Cl₂ / 0.5 h / Ambient temperature

With lead(IV) acetate; jones reagent; boron trifluoride diethyl etherate; iodine; sodium acetate; acetic acid; pyridinium chlorochromate; zinc; In methanol; dichloromethane; isopropyl alcohol; acetone;