6901-40-2

Basic information

• Product Name: 19-HYDROXYDEOXYCORTICOSTERONE*21-ACETATE
• Synonyms: 19-HYDROXYDEOXYCORTICOSTERONE*21-ACETATE;21-Acetoxy-19-hydroxy-4-pregnene-3,20-dione;4-Pregnene-19,21-diol-3,20-dione 21-acetate
• CAS NO: 6901-40-2
• Molecular Formula: C23H32O5
• Molecular Weight: 388.5
• Mol File: 6901-40-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 19-HYDROXYDEOXYCORTICOSTERONE*21-ACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: 19-HYDROXYDEOXYCORTICOSTERONE*21-ACETATE(6901-40-2)
• EPA Substance Registry System: 19-HYDROXYDEOXYCORTICOSTERONE*21-ACETATE(6901-40-2)

Safety Data

• Hazardous Substances Data: 6901-40-2(Hazardous Substances Data)

Usage

Chemical compound

A derivative of deoxycorticosterone, a hormone produced by the adrenal glands.

Steroid hormone

Belongs to the class of steroid hormones.

Structural features

Contains a 21-acetate group and a hydroxy group at the 19th carbon position.

Medical applications

Studied for potential use in treating various conditions such as inflammation, hormonal imbalances, and autoimmune diseases.

Diagnostic potential

Being researched as a diagnostic tool for adrenal disorders.

Ongoing research

The precise mechanisms of action and potential therapeutic uses are still under investigation.

Fields of relevance

Shows promise as a valuable tool in the fields of endocrinology and pharmacology.

Upstream product

• 64-19-7 acetic acid 
• 104494-67-9 19-t-butyldimethylsilyloxydeoxycorticosterone 21-acetate 
• 2685-64-5 5-bromo-6β,19-oxido-3β-hydroxy-5α-androstan-17-one 3-acetate 
• 104494-72-6 t-butyl 3β-t-butyldimethylsilyloxy-19-(2-tetrahydropyranyloxy)-20-methoxypregna-5,17(20)-dien-21-oate 
• 104494-70-4 methyl 3β-t-butyldimethylsilyloxy-19-(2-tetrahidropyranyloxy)-20-methoxypregna-5,17(20)-dien-21-oate 
• 104494-74-8 2-[(3S,8S,9S,10S,13S,14S)-3-(tert-Butyl-dimethyl-silanyloxy)-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-2-methoxy-ethanol 
• 104494-76-0 Acetic acid 2-[(3S,8S,9S,10S,13S,14S)-3-hydroxy-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-(17Z)-ylidene]-2-methoxy-ethyl ester 
• 104494-69-1 3β-t-butyldimethylsilyloxy-19-(2-tetrahydropyranyloxy)-androst-5-en-17-one 
• 104494-66-8 19-t-butyldimethylsilyloxy-3-(N-pyrrolidinyl)-pregna-3,5-dien-20-one 
• 104494-65-7 19-t-butyldimethylsilyloxyprogesterone 
• 104494-64-6 1-[(3S,8S,9S,10S,13S,14S,17S)-10-(tert-Butyl-dimethyl-silanyloxymethyl)-3-hydroxy-13-methyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-ethanone 
• 31751-06-1 (3S,8R,9S,10S,13S,14S)-3-Hydroxy-13-methyl-10-(tetrahydro-pyran-2-yloxymethyl)-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydro-cyclopenta[a]phenanthren-17-one 
• 4229-69-0 3β-acetoxy-5-bromo-6β-hydroxy-5α-androstan-17-one 
• 853-23-6 prasterone acetate 

Downstream Products

• 4682-70-6 19-Nordeoxycorticosterone 
• 75220-37-0 19-oxo-deoxycorticosterone 
• 2394-23-2 19,21-dihydroxypregn-4-ene-3,20-dione 
• 88378-35-2 19-oxo-11-deoxycorticosterone acetate 

Relevant articles and documents

Synthesis of 6,19-cyclopregnanes. Constrained analogues of steroid hormones

A procedure for the synthesis of 6,19-cyclopregnanes is described involving an intramolecular alkylation reaction of Δ4-3-keto steroids with a 19-mesylate in the presence of KOH in isopropanol. Three 6,19-cyclopregnanes were prepared (4, 5, 9); in the rat, 6,19-cycloprogesterone (4) and its 21-hydroxy derivative 5 displaced [3H]-dexamethasone from glucocorticoid receptors, the former compound being more active. Both compounds did not compete with [3H]-aldosterone for kidney mineralocorticoid receptors nor with [3H]-R5020 for uterus progesterone receptors. This journal is The Royal Society of Chemistry.

Convenient preparative routes to 19-hydroxy, 19-oxo-, 19-oic-, and 19-nor-deoxycorticosterone

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New Syntheses of 19,21-Dihydropregn-4-ene-3,20-dione, 21-Hydroxy-19-norpregn-4-ene-3,20-dione, and 11β,19,21-trihydroxypregn-4-ene-3,20-dione

19,21-Dihydroxypregn-4-ene-3,20-dione has been synthesized from 3β-acetoxypregn-5-en-20-one via the "hypoiodite reaction" , and Henbest acetoxylation at C-21; oxidation of the intermediate 21-monoacetate to 19-oxo derivative and alkaline cleavage gave 21-hydroxy-19-norpregn-4-ene-3,20-dione.A similar synthesis of 11β,19,21-trihydroxypregn-4-ene-3,20-dione from 3β-acetoxypregn-5-ene-11,20-dione proceeded through intermediates with the 11β-hydroxy function protected as its acetate.Unusual features mainly of conformational origin were observed in the presence of the 11β-acetoxy substituent; some were helpful to the synthesis, while others led to undesirable side reactions.