6-chloro-2-methyl-4(1H)-quinazolinone

Base Information

• Chemical Name: 6-chloro-2-methyl-4(1H)-quinazolinone
• CAS No.: 7142-09-8
• Molecular Formula: C9H7 Cl N2 O
• Molecular Weight: 194.62
• Hs Code.: 2933990090
• Mol file: 7142-09-8.mol

Synonyms:4(1H)-Quinazolinone,6-chloro-2-methyl- (9CI); 6-Chloro-2-methylquinazolin-4(3H)-one;6-Chloro-4-hydroxy-2-methylquinazoline; NSC 45786

Chemical Property of 6-chloro-2-methyl-4(1H)-quinazolinone

Chemical Property:

• Vapor Pressure: 3.2E-05mmHg at 25°C
• Refractive Index: 1.5330 (estimate)
• Boiling Point: 355.1°C at 760 mmHg
• Flash Point: 168.6°C
• PSA: 45.75000
• Density: 1.43
• LogP: 1.88490
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-4-hydroxy-2-methylquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-chloro-2-methyl-4(1H)-quinazolinone

There total 1 articles about 6-chloro-2-methyl-4(1H)-quinazolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-acetylamino-5-chloro-benzoic acid amide (7033-53-6) → 6-chloro-2-methylquinazolin-4-(3H)-one (7142-09-8) + 2-acetamido-5-chlorobenzoic acid (5202-87-9)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01187a033

Reference yield: 95.0%

6-chloro-2-methylquinazolin-4-(3H)-one (7142-09-8) + 4-methoxy-benzaldehyde (123-11-5) → 6-chloro-2-[(E)-2-(4-methoxyphenyl)ethenyl]quinazolin-4(3H)-one

Guidance literature:

With sulfuric acid; at 190 ℃; for 2h; Microwave irradiation;

Reference yield: 85.9%

6-chloro-2-methylquinazolin-4-(3H)-one (7142-09-8) + 4-chlorobenzaldehyde (104-88-1) → 6-chloro-2-[(E)-2-(4-chlorophenyl)ethenyl]quinazolin-4(3H)-one (1123685-09-5)

Guidance literature:

With acetic acid; at 120 ℃; for 12h;

DOI:10.1016/j.bmc.2008.11.012

upstream raw materials:

2-acetylamino-5-chloro-benzoic acid amide

Downstream raw materials:

6-chloro-2-[(E)-2-(4-chlorophenyl)ethenyl]quinazolin-4(3H)-one

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