6-BROMOCHROMONE

Base Information

• Chemical Name: 6-BROMOCHROMONE
• CAS No.: 51483-92-2
• Molecular Formula: C9H5BrO2
• Molecular Weight: 225.041
• Hs Code.: 29329990
• Mol file: 51483-92-2.mol

Synonyms:6-Bromo-4H-chromen-4-one;

Chemical Property of 6-BROMOCHROMONE

Chemical Property:

• Vapor Pressure: 0.000793mmHg at 25°C
• Melting Point: 135-139 °C (dec.)(lit.)
• Refractive Index: 1.63
• Boiling Point: 306 °C at 760 mmHg
• Flash Point: 138.9 °C
• Density: 1.688 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Bromo-4H-chromen-4-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 6-BROMOCHROMONE

There total 13 articles about 6-BROMOCHROMONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(E)-1-(5-bromo-2-hydroxyphenyl)-3-(dimethylamino)prop-2-en-1-one → 6-bromo-1-benzopyran-4(4H)-one (51483-92-2)

Guidance literature:

With chloro-trimethyl-silane; In N,N-dimethyl-formamide; at 90 - 120 ℃; Inert atmosphere;

DOI:10.1039/c1ob06494k

Reference yield: 91.0%

5-Bromo-2-hydroxyacetophenone (1450-75-5) + formic acid ethyl ester (109-94-4) → 6-bromo-1-benzopyran-4(4H)-one (51483-92-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; Inert atmosphere;

DOI:10.1039/d1cc03708k

Reference yield: 43.0%

6-bromochroman-4-one (49660-57-3) → 6-bromo-1-benzopyran-4(4H)-one (51483-92-2)

Guidance literature:

With iodine; In dimethyl sulfoxide; for 2h; Reflux;

DOI:10.1071/CH10295

upstream raw materials:

6-bromo-4-oxo-4H-chromene-3-carboxylic acid

6-bromo-4-oxo-4H-chromene-3-carbaldehyde

6-bromochroman-4-one

4-bromo-phenol

Downstream raw materials:

ALW-II-49-5

(2S,4R)-6-bromo-3,4-dihydro-2,4-diphenyl-2H-1-benzopyran-4-ol

7-(5-bromo-2-hydroxyphenyl)-2-mercaptopyrido[2,3-d]pyrimidin-4-ol

4-bromo-2-(2-(piperidin-1-yl)thiazolo[4,5-b]pyridin-5-yl)phenol