1-phenylbutane-1,2-dione

Base Information

• Chemical Name: 1-phenylbutane-1,2-dione
• CAS No.: 3457-55-4
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol file: 3457-55-4.mol

Synonyms:1-Phenyl-1,2-butanedione;

Chemical Property of 1-phenylbutane-1,2-dione

Chemical Property:

• Vapor Pressure: 0.0281mmHg at 25°C
• Refractive Index: 1.515
• Boiling Point: 245.848 °C at 760 mmHg
• Flash Point: 92.545 °C
• Density: 1.073 g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-phenylbutane-1,2-dione

There total 66 articles about 1-phenylbutane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

diethylmercury (627-44-1) + (benzoyl)PdI(triphenylphosphine)2 (50417-71-5,57129-77-8) → PhCEt(OH)COEt (6740-79-0) + 2-ethyl-2-hydroxy-1-phenylbutan-1-one (30239-74-8) + 1-phenyl-1,2-butanedione (3457-55-4) + 1-phenyl-propan-1-one (93-55-0)

Guidance literature:

With carbon monoxide; In tetrahydrofuran; High Pressure; 0.05 mmol Pd compound, 0.1 mmol Et2Hg, 2,5 ml THF, CO 30 atm (at -50°C), stirred for 2 h at 25°C in presence of 0.2 mmol MgClBr; GC-MS, GC;

DOI:10.1016/0022-328X(88)80680-6

Reference yield: 73.0%

1-phenyl-1-butyne (622-76-4,83585-27-7) → propionic acid (802294-64-0,79-09-4) + 1-phenyl-1,2-butanedione (3457-55-4) + benzoic acid (65-85-0,8013-63-6)

Guidance literature:

ruthenium(IV) oxide; In tetrachloromethane; at 15 - 20 ℃; electrolyse: aq. buffered NaCl (pH 4), platinum electrodes, 20 mA/cm², electricity: 6.7 F/mol;

DOI:10.1055/s-1987-27950

Reference yield: 56.0%

ethylzinc chloride (2633-75-2) + (benzoyl)PdI(triphenylphosphine)2 (50417-71-5,57129-77-8) → PhCEt(OH)COEt (6740-79-0) + 2-ethyl-2-hydroxy-1-phenylbutan-1-one (30239-74-8) + 1-phenyl-1,2-butanedione (3457-55-4) + 1-phenyl-propan-1-one (93-55-0)

Guidance literature:

With carbon monoxide; In tetrahydrofuran; High Pressure; 0.05 mmol Pd compound, 0.1 mmol EtZnCl, 2,5 ml THF, CO 30 atm (at -50°C), stirred for 2 h at 25°C in presence of 0.1 mmol MgClBr (yield of PhCEt(OH)COEt/PhCOCEt2(OH): 21%); GC-MS, GC;

DOI:10.1016/0022-328X(88)80680-6

upstream raw materials:

α-nitrato n-propyl phenyl ketone

benzoic acid ethyl ester

Ethyl propionate

propiophenone

Downstream raw materials:

2-ethylamino-1-phenyl-butan-1-ol

biphenyl

benzaldehyde

benzil