Quinoxaline-2-carbohydrazide

Base Information

• Chemical Name: Quinoxaline-2-carbohydrazide
• CAS No.: 54571-06-1
• Molecular Formula: C9H8N4O
• Molecular Weight: 188.189
• NSC Number: 123503
• DSSTox Substance ID: DTXSID10298496
• Wikidata: Q82040337
• ChEMBL ID: CHEMBL152088
• Mol file: 54571-06-1.mol

Synonyms:quinoxaline-2-carbohydrazide;54571-06-1;NSC123503;CHEMBL152088;SCHEMBL1147223;DTXSID10298496;AKOS008979896;2-Quinoxaline carboxylic acid hydrazide;NSC-123503;Quinoxaline-2-carboxylic acid hydrazide;AS-76920;D94314

Chemical Property of Quinoxaline-2-carbohydrazide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.368g/cm³
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 188.06981089
• Heavy Atom Count: 14
• Complexity: 221

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)N=CC(=N2)C(=O)NN

Technology Process of Quinoxaline-2-carbohydrazide

There total 10 articles about Quinoxaline-2-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

quinoxaline-2-carboxylic acid methyl ester (1865-11-8) → quinoxaline-2-carbohydrazide (54571-06-1)

Guidance literature:

With hydrazine hydrate; at 50 ℃; for 2h;

DOI:10.1021/jm020310n

Reference yield:

quinoxaline-2-carboxylic acid chloride (54745-92-5) → quinoxaline-2-carbohydrazide (54571-06-1)

Guidance literature:

With hydrazine hydrate;

Reference yield:

quinoxaline-2,3-dicarboxylic acid anhydride (5660-34-4) → quinoxaline-2-carbohydrazide (54571-06-1)

Guidance literature:

Multi-step reaction with 3 steps

2: 150 - 160 °C / unter vermindertem Druck

3: N₂H₄+H₂O

With hydrazine hydrate;

DOI:10.1248/cpb1953.5.277

upstream raw materials:

quinoxaline-2-carboxylic acid chloride

quinoxaline-2-carboxylic acid methyl ester

ethyl quinoxaline-2-carboxylate

phenyl quinoxaline-2-carboxylate

Downstream raw materials:

C₁₄H₁₈N₆OS

4-(4-amino-butyl)-5-quinoxalin-2-yl-4H-[1,2,4]triazole-3-thiol