N-phenylphenylalaninamide

Base Information

• Chemical Name: N-phenylphenylalaninamide
• CAS No.: 5426-73-3
• Molecular Formula: C15H16N2O
• Molecular Weight: 240.305
• Mol file: 5426-73-3.mol

Synonyms:

Chemical Property of N-phenylphenylalaninamide

Chemical Property:

• Vapor Pressure: 7.96E-09mmHg at 25°C
• Boiling Point: 465°Cat760mmHg
• Flash Point: 235°C
• Density: 1.179g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-phenylphenylalaninamide

There total 38 articles about N-phenylphenylalaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N2-<(tert-butoxy)carbonyl>-L-phenylalanine phenylamide (113035-40-8) → L-phenylalanineanilide (5426-73-3,15423-54-8,16876-72-5,55685-43-3)

Guidance literature:

N²-<(tert-butoxy)carbonyl>-L-phenylalanine phenylamide; With hydrogenchloride; In 1,4-dioxane; for 2h; Cooling with ice;

With sodium hydroxide; In water; pH=11;

Reference yield: 96.0%

(S)-benzyl (1-oxo-3-phenyl-1-(phenylamino)propan-2-yl)carbamate (15366-12-8) → L-phenylalanineanilide (5426-73-3,15423-54-8,16876-72-5,55685-43-3)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; under 750.075 Torr;

DOI:10.1007/s11172-013-0132-z

Reference yield: 96.0%

iodobenzene (591-50-4) + L-Phenylalanine amide (5241-58-7) → L-phenylalanineanilide (5426-73-3,15423-54-8,16876-72-5,55685-43-3)

Guidance literature:

With copper(l) iodide; potassium carbonate; In toluene; at 110 ℃; for 24h; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201200752

upstream raw materials:

aniline

N-phthaloylphenylalanine

bromobenzene

(R,S)-2-amino-3-phenylpropionamide

Downstream raw materials:

[(R)-3-Methyl-1-((S)-2-phenyl-1-phenylcarbamoyl-ethylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

(S)-2-((S)-2-Phenyl-1-phenylcarbamoyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

(S)-N-benzoyl-phenylalanine anilide

C₂₂H₂₄N₂