(3R,5R)-5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

Base Information

Chemical Name:(3R,5R)-5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine
CAS No.:114372-38-2
Molecular Formula:C₂₁H₂₁Cl₂N₃O₂
Molecular Weight:418.323
Hs Code.:
DSSTox Substance ID:DTXSID70921339
Wikidata:Q82894153
Mol file:114372-38-2.mol

Synonyms:5-((4-chlorophenoxy)methyl)-3-(4-chlorophenyl)-3-((1H-imidazol-1-yl)methyl)-2-methylisoxazolidine;PR 967-248;PR 967248;PR-967-248

Suppliers and Price of (3R,5R)-5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-((4-CHLOROPHENOXY)METHYL)-3-(4-CHLOROPHENYL)-3-((1H-IMIDAZOL-1-YL)METHYL)-2-METHYLISOXAZOLIDINE 95.00%
5MG
$ 498.21

Total 1 raw suppliers

Chemical Property of (3R,5R)-5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

Chemical Property:

Vapor Pressure:4.53E-13mmHg at 25°C
Boiling Point:571.5°Cat760mmHg
Flash Point:299.4°C
PSA：39.52000
Density:1.31g/cm³
LogP:4.73800
XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:417.1010823
Heavy Atom Count:28
Complexity:498

Purity/Quality:: 5-((4-CHLOROPHENOXY)METHYL)-3-(4-CHLOROPHENYL)-3-((1H-IMIDAZOL-1-YL)METHYL)-2-METHYLISOXAZOLIDINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(CC(O1)COC2=CC=C(C=C2)Cl)(CN3C=CN=C3)C4=CC=C(C=C4)Cl
Isomeric SMILES:CN1[C@@](C[C@@H](O1)COC2=CC=C(C=C2)Cl)(CN3C=CN=C3)C4=CC=C(C=C4)Cl

Technology Process of (3R,5R)-5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

There total 5 articles about (3R,5R)-5-[(4-chlorophenoxy)methyl]-3-(4-chlorophenyl)-3-(imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.5%

: 13997-70-1
1-allyloxy-4-chlorobenzene

: 119393-45-2,113944-25-5
1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide

: 114372-39-3
trans-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine

: 114372-38-2
cis-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine

Guidance literature:: In toluene; for 46h; Heating;
DOI:10.1002/hlca.19880710406

Reference yield:

: 24155-32-6
1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one

: 114372-38-2
cis-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 54 percent / AcONa / ethanol / 48 h / Ambient temperature

2: 63.5 percent / toluene / 46 h / Heating

With sodium acetate; In ethanol; toluene;
DOI:10.1002/hlca.19880710406

Reference yield:

: 106-48-9,82344-39-6
4-chloro-phenol

: 114372-38-2
cis-5-<(4-chlorophenoxy)methyl>-3-(4-chlorophenyl)-3-<(1H-imidazol-1-yl)methyl>-2-methylisoxazolidine

Guidance literature:: Multi-step reaction with 2 steps

2: 63.5 percent / toluene / 46 h / Heating

In toluene;
DOI:10.1002/hlca.19880710406