2-[2-(acetylamino)-6-oxo-3,6-dihydropyrimidin-4-yl]-2-oxoethyl 3,3,3-trichloropropanoate

Base Information

• Chemical Name: 2-[2-(acetylamino)-6-oxo-3,6-dihydropyrimidin-4-yl]-2-oxoethyl 3,3,3-trichloropropanoate
• CAS No.: 86944-34-5
• Molecular Formula: C₁₁H₁₀Cl₃N₃O₆
• Molecular Weight: 386.576
• Mol file: 86944-34-5.mol

Synonyms:

Chemical Property of 2-[2-(acetylamino)-6-oxo-3,6-dihydropyrimidin-4-yl]-2-oxoethyl 3,3,3-trichloropropanoate

Chemical Property:

• Density: 1.65g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[2-(acetylamino)-6-oxo-3,6-dihydropyrimidin-4-yl]-2-oxoethyl 3,3,3-trichloropropanoate

There total 5 articles about 2-[2-(acetylamino)-6-oxo-3,6-dihydropyrimidin-4-yl]-2-oxoethyl 3,3,3-trichloropropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-acetamido-6-(hydroxyacetyl)-4(1H)-pyrimidinone (86944-33-4) + 2,2,2-Trichloroethyl chloroformate (17341-93-4) → 2-acetamido-6-<<<(β,β,β-trichloroethoxy)carbonyl>oxy>acetyl>-4(1H)-pyrimidinone (86944-34-5)

Guidance literature:

With pyridine; at 55 ℃; for 0.0833333h;

DOI:10.1021/jo00169a001

Reference yield:

ethyl 3-oxo-4,4-diethoxypentanoate (6312-89-6) → 2-acetamido-6-<<<(β,β,β-trichloroethoxy)carbonyl>oxy>acetyl>-4(1H)-pyrimidinone (86944-34-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 42 percent / ethanol / 17 h / Heating

2: 67 percent / 0.17 h / 100 °C

3: 95 percent / toluenesulfonic acid / xylene / 0.25 h / Heating

4: 78 percent / peracetic acid / tetrahydrofuran; H₂O / 4.5 h / 45 °C

5: 95 percent / pyridine / 0.08 h / 55 °C

With pyridine; peracetic acid; o-toluenesulfonic acid; In tetrahydrofuran; ethanol; water; xylene;

DOI:10.1021/jo00169a001

Reference yield:

2-amino-6-(1,1-diethoxyethyl)-4(1H)-pyrimidinone (86944-23-2) → 2-acetamido-6-<<<(β,β,β-trichloroethoxy)carbonyl>oxy>acetyl>-4(1H)-pyrimidinone (86944-34-5)

Guidance literature:

Multi-step reaction with 4 steps

1: 67 percent / 0.17 h / 100 °C

2: 95 percent / toluenesulfonic acid / xylene / 0.25 h / Heating

3: 78 percent / peracetic acid / tetrahydrofuran; H₂O / 4.5 h / 45 °C

4: 95 percent / pyridine / 0.08 h / 55 °C

With pyridine; peracetic acid; o-toluenesulfonic acid; In tetrahydrofuran; water; xylene;

DOI:10.1021/jo00169a001

upstream raw materials:

2-acetamido-6-(hydroxyacetyl)-4(1H)-pyrimidinone

2,2,2-Trichloroethyl chloroformate

ethyl 3-oxo-4,4-diethoxypentanoate

2-amino-6-(1,1-diethoxyethyl)-4(1H)-pyrimidinone