Chemical Property of 2,2,2-Trichloroethyl chloroformate
Chemical Property:
- Appearance/Colour:Clear light yellow liquid
- Vapor Pressure:0.06 psi ( 20 °C)
- Melting Point:1 °C
- Refractive Index:n20/D 1.471(lit.)
- Boiling Point:171.499 °C at 760 mmHg
- Flash Point:82.079 °C
- PSA：26.30000
- Density:1.666 g/cm3
- LogP:2.73200
- Storage Temp.:2-8°C
- Sensitive.:Moisture Sensitive
- Water Solubility.:Soluble in Ether, Benzene, Chloroform, Ethanol. Insoluble in water.
- XLogP3:3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:211.877940
- Heavy Atom Count:9
- Complexity:107
- Purity/Quality:
-
99% *data from raw suppliers
2,2,2-Trichloroethyl Chloroformate *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
23-34-36
- Safety Statements:
26-36/37/39-45-7/9
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:Toxic Gases & Vapors -> Acid Halides
- Canonical SMILES:C(C(Cl)(Cl)Cl)OC(=O)Cl
-
Uses
2,2,2-Trichloroethyl chloroformate is used as a protecting reagent for aliphatic and aromatic hydroxyl and amino groups. It is used as derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samples, during N-demethylation of dextromethorphan. It was used as starting reagent during the synthesis of 6-Nor-9,10-dihydrolysergic acid methyl ester. 2,2,2-Trichloroethyl chloroformate was used as:derivatizing reagent in gas chromatographic/mass spectrometric determination of a large range of amphetamine-related drugs and ephedrines in plasma, urine and hair samplesstarting reagent during the synthesis of 6-nor-9,10-dihydrolysergic acid methyl ester (IV)reagent during N-demethylation of dextromethorphanprotecting group reagent for amines and alcohols
