2-(2-Chloroanilino)acetohydrazide

Base Information

• Chemical Name: 2-(2-Chloroanilino)acetohydrazide
• CAS No.: 2371-29-1
• Molecular Formula: C₈H₁₀ClN₃O
• Molecular Weight: 199.64
• Hs Code.: 2928000090
• NSC Number: 190335
• DSSTox Substance ID: DTXSID20307184
• Wikidata: Q82054544
• ChEMBL ID: CHEMBL1450969
• Mol file: 2371-29-1.mol

Synonyms:2371-29-1;2-(2-chloroanilino)acetohydrazide;(2-Chloro-phenylamino)-acetic acid hydrazide;2-((2-Chlorophenyl)amino)acetohydrazide;2-[(2-chlorophenyl)amino]acetohydrazide;2-(2-chlorophenylamino)acetohydrazide;NSC190335;Oprea1_375972;Oprea1_570382;MLS000712201;CHEMBL1450969;DTXSID20307184;2-[(2-chlorophenyl)amino]acetohydrazide (non-preferred name);HMS2700M05;CAA37129;STK023432;AKOS000319499;NSC-190335;SMR000281968;(2-chlorophenylamino)acetic acid hydrazide;FT-0691494

Chemical Property of 2-(2-Chloroanilino)acetohydrazide

Chemical Property:

• Vapor Pressure: 1.16E-08mmHg at 25°C
• Boiling Point: 460.5°Cat760mmHg
• Flash Point: 232.3°C
• PSA: 67.15000
• Density: 1.358g/cm³
• LogP: 1.90600
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 199.0512396
• Heavy Atom Count: 13
• Complexity: 177

Purity/Quality:

98%min ^*data from raw suppliers

2-(2-Chloroanilino)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)NCC(=O)NN)Cl

Technology Process of 2-(2-Chloroanilino)acetohydrazide

There total 4 articles about 2-(2-Chloroanilino)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl N-(2-chlorophenyl)-N-(trifluoroacetyl)glycinate → 2-((2-chlorophenyl)amino)acetohydrazide (2371-29-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 90 ℃; for 16h;

DOI:10.1021/acs.jmedchem.7b00443

Reference yield:

N-(2-chlorophenyl)-2,2,2-trifluoro-acetamide (62926-91-4) → 2-((2-chlorophenyl)amino)acetohydrazide (2371-29-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: hydrazine hydrate / ethanol / 16 h / 90 °C

With hydrazine hydrate; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00443

Reference yield:

o-chloroaniline (95-51-2) → 2-((2-chlorophenyl)amino)acetohydrazide (2371-29-1)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 0.75 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: hydrazine hydrate / ethanol / 16 h / 90 °C

With hydrazine hydrate; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.7b00443

upstream raw materials:

N-(2-chlorophenyl)-2,2,2-trifluoro-acetamide

o-chloroaniline