N-MALEIMIDOMETHANOL

Base Information

• Chemical Name: N-MALEIMIDOMETHANOL
• CAS No.: 5063-96-7
• Molecular Formula: C₅H₅NO₃
• Molecular Weight: 127.1
• Hs Code.: 2925190090
• Mol file: 5063-96-7.mol

Synonyms:N-Methylolmaleimide;N-Hydroxymethyl-maleinimid;hydroxymethylmaleimide;N-hydroxymethylmaleimide;N-Maleimidemethanol;N-Maleimidomethanol;1-Hydroxymethyl-pyrrole-2,5-dione;Maleimide,N-(hydroxymethyl);

Chemical Property of N-MALEIMIDOMETHANOL

Chemical Property:

• Vapor Pressure: 0.000475mmHg at 25°C
• Melting Point: 100-103oC
• Boiling Point: 279.8°Cat760mmHg
• PKA: 12.69±0.10(Predicted)
• Flash Point: 123°C
• PSA: 57.61000
• Density: 1.501g/cm³
• LogP: -1.20090
• Storage Temp.: Hygroscopic, Refrigerator, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%min ^*data from raw suppliers

N-Maleimidomethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A sulfhydryl reactive crosslinking reagent A sulfhydryl reactive crosslinking reagent.

Technology Process of N-MALEIMIDOMETHANOL

There total 4 articles about N-MALEIMIDOMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.2%

maleiimide (541-59-3,25721-74-8) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → 1-hydroxymethyl-pyrrole-2,5-dione (5063-96-7)

Guidance literature:

In water; for 4h; Reflux;

DOI:10.1039/d0tc02721a

Reference yield:

maleiimide (541-59-3,25721-74-8) + 36%-formaldehyde → 1-hydroxymethyl-pyrrole-2,5-dione (5063-96-7)

Guidance literature:

Reference yield:

C5H7NO4 → 1-hydroxymethyl-pyrrole-2,5-dione (5063-96-7)

Guidance literature:

With sodium acetate; acetic anhydride; for 0.5h;

DOI:10.3390/ph13010016

upstream raw materials:

maleiimide

formaldehyd

Downstream raw materials:

N-<2-(morpholin-4-yl)methyl>maleimide

bis(maleimidomethyl) ether

N-anilinomethyl-maleimide

(2,5-dioxopyrrol-1-yl)methylpropanoate

Refernces

• 1、 Byrne, Andrew J.,Bright, Sandra A.,McKeown, James P.,O’brien, John E.,Twamley, Brendan,Fayne, Darren,Williams, D. Clive,Meegan, Mary J.. "Design, synthesis and biochemical evaluation of novel ethanoanthracenes and related compounds to target burkitt’s lymphoma". . . Retrieved 2020/01/31.
• 2、 -. "Maleimidyl-containing material and production method thereof". Page/Page column 6. . Retrieved 2010/11/08.