3,6-Dimethoxypyridazin-4-amine

Base Information

• Chemical Name: 3,6-Dimethoxypyridazin-4-amine
• CAS No.: 1075-68-9
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.156
• Hs Code.: 2933990090
• NSC Number: 114072
• DSSTox Substance ID: DTXSID50297105
• Nikkaji Number: J780.604C
• Wikidata: Q82038056
• Mol file: 1075-68-9.mol

Synonyms:3,6-dimethoxypyridazin-4-amine;1075-68-9;4-Pyridazinamine, 3,6-dimethoxy-;4-Pyridazinamine,3,6-dimethoxy-;NSC114072;SCHEMBL15941543;DTXSID50297105;NSC-114072

Chemical Property of 3,6-Dimethoxypyridazin-4-amine

Chemical Property:

• Vapor Pressure: 4.58E-06mmHg at 25°C
• Boiling Point: 382.9°Cat760mmHg
• Flash Point: 185.4°C
• PSA: 70.26000
• Density: 1.229g/cm³
• LogP: 0.65720
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 155.069476538
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,6-dimethoxy-4-Pyridazinamine 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NN=C(C(=C1)N)OC

Technology Process of 3,6-Dimethoxypyridazin-4-amine

There total 8 articles about 3,6-Dimethoxypyridazin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-azido-2,6-dimethoxypyridazine (2096-37-9) → 3,6-Dimethoxy-4-aminopyridazin (1075-68-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 760 Torr;

DOI:10.1055/s-1996-4303

Reference yield:

3,6-dimethoxypyridazine (4603-59-2) → 3,6-Dimethoxy-4-aminopyridazin (1075-68-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Buli, 2.) TsN₃ / 1.) THF, -75 deg C, 10 min, 2.) THF, -75 deg C, 2 h

2: 100 percent / H₂ / 10percent Pd/C / ethanol / 2 h / 760 Torr

With n-butyllithium; 4-toluenesulfonyl azide; hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1055/s-1996-4303

Reference yield:

3,6-Dimethoxy-1,4-dihydro-pyridazin-4-ylamine → 3,6-Dimethoxy-4-aminopyridazin (1075-68-9)

Guidance literature:

With potassium permanganate; In ammonia; for 30h; Yield given;

upstream raw materials:

N-(3,6-dimethoxy-pyridazin-4-yl)-acetamide

4-azido-2,6-dimethoxypyridazine

3,6-dimethoxypyridazine

3,6-dimethoxy-pyridazine 1-oxide

Refernces

• 1、 Tondys, Hanna,Plas, Henk C. van der. "Amination of 4-Nitropyridazine 1-Oxides by Liquid Ammonia/Potassium Permanganate". . p. 621 - 623. Retrieved 2007/10/02.