3,6-DIMETHOXYPYRIDAZINE

Base Information

• Chemical Name: 3,6-DIMETHOXYPYRIDAZINE
• CAS No.: 4603-59-2
• Molecular Formula: C6H8N2O2
• Molecular Weight: 140.142
• Hs Code.: 2933990090
• Mol file: 4603-59-2.mol

Synonyms:3,6-Bis-methoxy-pyridazin;3,6-dimethoxy-pyridazines;Pyridazine,3,6-diMethoxy;3,6-Dimethoxy-pyridazin;

Chemical Property of 3,6-DIMETHOXYPYRIDAZINE

Chemical Property:

• Vapor Pressure: 0.00239mmHg at 25°C
• Melting Point: 106 °C(Solv: water (7732-18-5))
• Boiling Point: 297.4°C at 760 mmHg
• PKA: 2.48±0.10(Predicted)
• Flash Point: 109.1°C
• PSA: 44.24000
• Density: 1.131g/cm³
• LogP: 0.49380
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3,6-Dimethoxypyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-DIMETHOXYPYRIDAZINE

There total 11 articles about 3,6-DIMETHOXYPYRIDAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + 3,6-dichlorpyridazine (141-30-0) + sodium methylate (124-41-4) → 3,6-dimethoxypyridazine (4603-59-2)

Guidance literature:

at 70 ℃;

Reference yield: 97.5%

methanol (67-56-1) + 3,6-dichlorpyridazine (141-30-0) → 3,6-dimethoxypyridazine (4603-59-2)

Guidance literature:

With sodium methylate; for 23h; Reflux;

Reference yield: 83.0%

benzyl vinyl ether (935-04-6) + 3,6-bis(methoxy)-1,2,4,5-tetrazine (81930-31-6) → 3,6-dimethoxypyridazine (4603-59-2)

Guidance literature:

In 1,4-dioxane; at 100 ℃; Sealed tube;

DOI:10.1002/asia.202100562

upstream raw materials:

3,6-dichlorpyridazine

sodium methylate

3-chloro-6-phenylsulfanyl-pyridazine

6-hydroxy-3-pyridazinone

Downstream raw materials:

6-methoxy-2-methylpyridazin-3(2H)-one

3,6-dimethoxy-pyridazine 1-oxide

3,6-dimethoxy-4-phenylpyridazine

(R)-3,6-dimethoxy-4-(p-tolylsulfinyl)pyridazine

Refernces

• 1、 Ananikov, Valentine P.,Ledovskaya, Maria S.,Polynski, Mikhail V.. "One-Pot and Two-Chamber Methodologies for Using Acetylene Surrogates in the Synthesis of Pyridazines and Their D-Labeled Derivatives". . p. 2286 - 2297. Retrieved 2021/07/20.
• 2、 Clapham, Kate M.,Batsanov, Andrei S.,Greenwood, Ryan D. R.,Bryce, Martin R.,Smith, Amy E.,Tarbit, Brian. "Functionalized heteroarylpyridazines and pyridazin-3(2H)-one derivatives via palladium-catalyzed cross-coupling methodology". . p. 2176 - 2181. Retrieved 2008/09/19.