4603-59-2

Basic information

• Product Name: 3,6-DIMETHOXYPYRIDAZINE
• Synonyms: 3,6-DIMETHOXYPYRIDAZINE;Pyridazine, 3,6-diMethoxy-
• CAS NO: 4603-59-2
• Molecular Formula: C₆H₈N₂O₂
• Molecular Weight: 140.14
• Mol File: 4603-59-2.mol

Chemical Properties

• Melting Point: 106 °C(Solv: water (7732-18-5))
• Boiling Point: 297.4°C at 760 mmHg
• Flash Point: 109.1°C
• Appearance: /
• Density: 1.131g/cm³
• Vapor Pressure: 0.00239mmHg at 25°C
• Refractive Index: 1.489
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 3,6-DIMETHOXYPYRIDAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-DIMETHOXYPYRIDAZINE(4603-59-2)
• EPA Substance Registry System: 3,6-DIMETHOXYPYRIDAZINE(4603-59-2)

Safety Data

• Hazardous Substances Data: 4603-59-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,6-Dimethoxypyridazine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block in the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
3,6-Dimethoxypyridazine is used as a reagent in the synthesis of other complex organic compounds. Its distinct chemical properties allow it to participate in various chemical reactions, contributing to the creation of new molecules with potential applications in different fields.
Used in Manufacturing:
3,6-Dimethoxypyridazine is used as a raw material in the production of certain industrial chemicals and materials. Its presence in the manufacturing process can influence the properties and performance of the final products, making it an important component in the development of new materials and technologies.
Used in Scientific Research:
3,6-Dimethoxypyridazine is used as a research compound in various scientific studies. Its unique chemical properties and potential reactivity make it an interesting subject for investigation, contributing to the advancement of knowledge in chemistry and related fields.

InChI:InChI=1/C6H8N2O2/c1-9-5-3-4-6(10-2)8-7-5/h3-4H,1-2H3

Upstream product

• 141-30-0 3,6-dichlorpyridazine 
• 124-41-4 sodium methylate 
• 64383-28-4 3-chloro-6-phenylsulfanyl-pyridazine 
• 123-33-1 6-hydroxy-3-pyridazinone 
• 77-78-1 dimethyl sulfate 
• 67-56-1 methanol 
• 75-77-4 chloro-trimethyl-silane 
• 262353-13-9 4-iodo-3,6-dimethoxypyridazine 
• 100-52-7 benzaldehyde 
• 623-49-4 ethyl cyanoformate 
• 262353-20-8 4,5-diiodo-3,6-dimethoxypyridazine 
• 935-04-6 benzyl vinyl ether 
• 81930-31-6 3,6-bis(methoxy)-1,2,4,5-tetrazine 

Downstream Products

• 7154-81-6 6-methoxy-2-methylpyridazin-3(2H)-one 
• 1703-08-8 3,6-dimethoxy-pyridazine 1-oxide 
• 126327-66-0 (3,6-dimethoxypyridazin-4-yl)phenylmethanol 
• 89943-29-3 4-Methyl-3,6-dimethoxy-pyridazin 
• 1703-10-2 6-Methoxy-3(2H)-pyridazinon 
• 110-16-7 maleic acid 
• 91392-56-2 3,6-dimethoxy-4-phenylpyridazine 
• 229179-84-4 (R)-3,6-dimethoxy-4-(p-tolylsulfinyl)pyridazine 
• 229179-83-3 (S)-3,6-dimethoxy-4-(p-tolylsulfinyl)pyridazine 
• 1015480-87-1 (3,6-dimethoxypyridazin-4-yl)boronic acid 
• 1072855-18-5 (3S)-N,N-dibenzyl-5-(3,6-dimethoxypyridazin-4-yl)chroman-3-amine 
• 1190764-67-0 C₁₉H₁₆ClF₃N₄O₅S 
• 41374-00-9 4-(4-chlorophenyl)-3,6-dimethoxypyridazine 
• 1190764-77-2 (3,6-dimethoxy-pyridazin-4-ylmethyl)-carbamic acid benzyl ester 

Relevant articles and documents

N -Chlorinative Ring Contraction of 1,4-Dimethoxyphthalazines via a Bicyclization/Ring-Opening Mechanism

An unprecedented N -chlorinative ring contraction of 1,2-diazines was discovered and investigated with an electrophilic chlorinating reagent, trichloroisocyanuric acid (TCICA). Through optimization and mechanistic analysis, the assisting role of n -Bu 4NCl as an exogenous nucleophile was identified, and the optimized reaction conditions were applied to a range of 1,4-dimethoxyphthalazine derivatives. Also, an improvement of overall efficiency was demonstrated by the use of a labile O -silyl group. A bicyclization/ring-opening mechanism, inspired by the Favorskii rearrangement, was proposed and supported by the DFT calculations. Furthermore, the efforts on scope expansion as well as the evaluation of other electrophilic promoters revealed that the newly developed ring contraction reactivity is a unique characteristic of 1,4-dimethoxyphthalazine scaffold and TCICA.

One-Pot and Two-Chamber Methodologies for Using Acetylene Surrogates in the Synthesis of Pyridazines and Their D-Labeled Derivatives

Acetylene surrogates are efficient tools in modern organic chemistry with largely unexplored potential in the construction of heterocyclic cores. Two novel synthetic paths to 3,6-disubstituted pyridazines were proposed using readily available acetylene surrogates through flexible C2 unit installation procedures in a common reaction space mode (one-pot) and distributed reaction space mode (two-chamber): (1) an interaction of 1,2,4,5-tetrazine and its acceptor-functionalized derivatives with a CaC2?H2O mixture performed in a two-chamber reactor led to the corresponding pyridazines in quantitative yields; (2) [4+2] cycloaddition of 1,2,4,5-tetrazines to benzyl vinyl ether can be considered a universal synthetic path to a wide range of pyridazines. Replacing water with D2O and vinyl ether with its trideuterated analog in the developed procedures, a range of 4,5-dideuteropyridazines of 95–99% deuteration degree was synthesized for the first time. Quantum chemical modeling allowed to quantify the substituent effect in both synthetic pathways.

CINNOLINE COMPOUNDS, THEIR PREPARATION, AND THEIR USE

The present invention relates to cinnoline compounds, particularly 4-amino-N-cyclopropyl- 7-fluoro-8-(3,6-dimethoxypyridazin-4-yl)cinnoline-3-carboxamide and salts thereof. The claimed invention also relates to compositions comprising such a compound, as

Functionalized heteroarylpyridazines and pyridazin-3(2H)-one derivatives via palladium-catalyzed cross-coupling methodology

(Chemical Equation Presented) A general method for the synthesis of functionalized pyridazinylboronic acids/esters is described involving a directed ortho metalation (DoM)-boronation protocol (Schemes 1 and 2). A comprehensive study of the reactivity of t

Compounds and Uses Thereof - 848

This invention relates to novel compounds having the structural formula I below: and their pharmaceutically acceptable salts, tautomers or in vivo-hydrolysable precursors, compositions and methods of use thereof, wherein R1, R2, Rsu

First study of syntheses and reactivity of Grignard compounds in the diazine series. Diazines. Part 27

A preparation of Grignard derivatives of diazines is described using a halogen magnesium exchange reaction. This convenient method allows the functionalization of these rings at 0°C or even room temperature.

Synthesis of some 3,6-disubstituted pyridazines

Some novel 3-halo-6-(4-substituted-phenoxy)pyridazines and 3,6-di-(4- substituted-phenoxy)pyridazines were synthesized from 3,6-dichloropyridazine or 3,6-diiodopyridazine. 3,6-Diiodopyridazine was prepared from 3,6- dichloropyridazine using hydriodic acid/iodine monochloride.

EXHAUSTIVE METHYLATION OF TAUTOMERIC 6-HYDROXY-3(2H)-PYRIDAZINONE AND ITS 2-METHYL- OR 2-PHENYL DERIVATIVES, FOLLOWED BY ISOLATION AND DETERMINATION BY COLUMN CHROMATOGRAPHY AND 1H NMR SPECTRA

Tautomeric 6-hydroxy-3(2H)-pyridazinone (1,2-dihydro-3,6-pyridazinone or 3,6-dihydroxypyridazine) and its N-methyl- and N-phenyl derivatives had been exhaustively methylated.The resulting N-methylated and O-methylated products were indentified by the 1H N