N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-chloroacetamide

Base Information

• Chemical Name: N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-chloroacetamide
• CAS No.: 32519-70-3
• Molecular Formula: C8H9 Cl N2 O2 S
• Molecular Weight: 232.691
• Hs Code.: 2934100090
• DSSTox Substance ID: DTXSID10366523
• Wikidata: Q82151773
• Mol file: 32519-70-3.mol

Synonyms:N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-chloroacetamide;32519-70-3;Acetamide,N-(5-acetyl-4-methyl-2-thiazolyl)-2-chloro-;DTXSID10366523;AKOS002951737;CS-0294476;EN300-09329;N-(5-Acetyl-4-methylthiazol-2-yl)-2-chloroacetamide;Z56974914

Chemical Property of N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-chloroacetamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 90.79000
• Density: 1.415g/cm³
• LogP: 2.48090
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 232.0073264
• Heavy Atom Count: 14
• Complexity: 250

Purity/Quality:

97% ^*data from raw suppliers

N-(5-ACETYL-4-METHYL-1,3-THIAZOL-2-YL)-2-CHLOROACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(SC(=N1)NC(=O)CCl)C(=O)C

Technology Process of N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-chloroacetamide

There total 5 articles about N-(5-acetyl-4-methyl-1,3-thiazol-2-yl)-2-chloroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-acetyl-4-methylthiazole-2-amine (30748-47-1) + chloroacetyl chloride (79-04-9) → N-(5-acetyl-4-methylthiazol-2-yl)-2-chloroacetamide (32519-70-3)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1016/j.bmc.2010.11.062

Reference yield:

5-acetyl-4-methylthiazole-2-amine (30748-47-1) → N-(5-acetyl-4-methylthiazol-2-yl)-2-chloroacetamide (32519-70-3)

Guidance literature:

With chloroacetyl chloride; In N,N-dimethyl-formamide; at 20 ℃; for 6h;

DOI:10.1016/j.ejmech.2018.10.008

Reference yield:

acetylacetone (123-54-6,81235-32-7) → N-(5-acetyl-4-methylthiazol-2-yl)-2-chloroacetamide (32519-70-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuryl dichloride / toluene / 72 h / 20 °C

2: ethanol / 3 h / Reflux

3: chloroacetyl chloride / N,N-dimethyl-formamide / 6 h / 20 °C

With sulfuryl dichloride; chloroacetyl chloride; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1016/j.ejmech.2018.10.008

upstream raw materials:

5-acetyl-4-methylthiazole-2-amine

chloroacetyl chloride

acetylacetone

3-chloropentane-2,4-dione