2',4-Dihydroxy-4',6'-dimethoxychalcone

Base Information

Chemical Name:2',4-Dihydroxy-4',6'-dimethoxychalcone
CAS No.:37308-75-1
Molecular Formula:C17H16O5
Molecular Weight:300.311
Hs Code.:
UNII:5LE8KTR6G2
DSSTox Substance ID:DTXSID60958437
Nikkaji Number:J17.571D,J647.134J
Wikipedia:Flavokavain_C
Wikidata:Q5458168
Metabolomics Workbench ID:26796
ChEMBL ID:CHEMBL251958
Mol file:37308-75-1.mol

Synonyms:flavokawain C

Suppliers and Price of 2',4-Dihydroxy-4',6'-dimethoxychalcone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Flavokawain C
20mg
$ 638.00

TRC
FlavokawainC
500mg
$ 715.00

ChemScene
FlavokawainC ≥98.0%
20mg
$ 571.00

ChemScene
FlavokawainC ≥98.0%
10mg
$ 336.00

ChemScene
FlavokawainC ≥98.0%
5mg
$ 198.00

Biorbyt Ltd
Flavokawain C 98%
100 mg
$ 1173.00

AvaChem
Flavokavain C
10mg
$ 189.00

AvaChem
Flavokavain C
5mg
$ 95.00

AvaChem
Flavokavain C
25mg
$ 369.00

American Custom Chemicals Corporation
(E)-1-(2-HYDROXY-4,6-DIMETHOXY PHENYL)-3-(4-HYDROXY PHENYL)PROP-2-EN-1-ONE 95.00%
10MG
$ 612.44

Total 27 raw suppliers

Chemical Property of 2',4-Dihydroxy-4',6'-dimethoxychalcone

Chemical Property:

Melting Point:179-182 °C
Boiling Point:556.0±50.0 °C(Predicted)
PKA:6.91±0.40(Predicted)
PSA：75.99000
Density:1.279±0.06 g/cm3(Predicted)
LogP:3.01110
XLogP3:3.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:300.09977361
Heavy Atom Count:22
Complexity:387

Purity/Quality:

≥98% ^*data from raw suppliers

Flavokawain C ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C(=C1)OC)C(=O)C=CC2=CC=C(C=C2)O)O
Isomeric SMILES:COC1=CC(=C(C(=C1)OC)C(=O)/C=C/C2=CC=C(C=C2)O)O
Uses Flavokawain C?is a?chalcone found in the kava plant. Studies showed that?Flavokawain C can inhibit cell cycle and promote apoptosis in HCT 116 cells. In addition, natural chalcones have been?implicated as lead compounds for developing dual inhibitors against?Histone deacetylase enzymes (HDACs) and NF-κB. Flavokawain C is a related compound Flavokawain A (F371020).

Technology Process of 2',4-Dihydroxy-4',6'-dimethoxychalcone

There total 8 articles about 2',4-Dihydroxy-4',6'-dimethoxychalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 19158-99-7
2’,4’-dimethoxy-6’-hydroxy-4-O-benzylchalcone

: 37308-75-1
flavokawain C

Guidance literature:: With boron trichloride; In dichloromethane; at 0 - 20 ℃;
DOI:10.2174/1570180817999200531162015

Reference yield: 70.0%

: 77184-69-1
2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone

: 37308-75-1
flavokawain C

Guidance literature:: With hydrogenchloride; In methanol; water; for 0.25h; Reflux;
DOI:10.1021/np800188b

Reference yield: 51.0%

: 90-24-4
2-hydroxy-4,6-dimethoxyacetophenone

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 37308-75-1
flavokawain C

Guidance literature:: 2-hydroxy-4,6-dimethoxyacetophenone; With sodium hydroxide; In methanol; at 0 ℃; for 0.5h; Inert atmosphere;

4-hydroxy-benzaldehyde; In methanol; Inert atmosphere;
DOI:10.1016/j.ejmech.2020.112216