2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone

Base Information

• Chemical Name: 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone
• CAS No.: 77184-69-1
• Molecular Formula: C₁₉H₂₀O₆
• Molecular Weight: 344.364
• Mol file: 77184-69-1.mol

Synonyms:2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone

Chemical Property of 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone

There total 4 articles about 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-hydroxy-4,6-dimethoxyacetophenone (90-24-4) + 4-methoxymethoxy-benzaldehyde (6515-21-5) → 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone (77184-69-1)

Guidance literature:

With potassium hydroxide; at 20 ℃; for 73h; Inert atmosphere; Cooling with ice;

DOI:10.1021/np800188b

Reference yield:

3,5-dihydroxyphenol (108-73-6) → 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone (77184-69-1)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc(II) chloride; hydrogenchloride / diethyl ether / 6 h / Cooling with ice

2: potassium carbonate / acetone / 1.5 h / Reflux

3: potassium hydroxide / methanol / 48 h / 20 °C

With hydrogenchloride; potassium carbonate; potassium hydroxide; zinc(II) chloride; In methanol; diethyl ether; acetone;

Reference yield:

2,4,6-trihydroxyacetophenone (480-66-0,67471-34-5) → 2’,4’-dimethoxy-6’-hydroxy-4-O-methoxymethylchalcone (77184-69-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 1.5 h / Reflux

2: potassium hydroxide / methanol / 48 h / 20 °C

With potassium carbonate; potassium hydroxide; In methanol; acetone;

upstream raw materials:

2-hydroxy-4,6-dimethoxyacetophenone

4-methoxymethoxy-benzaldehyde

3,5-dihydroxyphenol

2,4,6-trihydroxyacetophenone

Downstream raw materials:

flavokawain C

4',6'-dimethoxy-2',4-dihydroxychalcone