Benzenamide, N-ethyl-N,4-dimethyl-

Base Information

• Chemical Name: Benzenamide, N-ethyl-N,4-dimethyl-
• CAS No.: 35113-87-2
• Molecular Formula: C10H15N
• Molecular Weight: 149.236
• DSSTox Substance ID: DTXSID40188614
• Nikkaji Number: J1.200.423K,J473.827F
• Wikidata: Q83060427
• Mol file: 35113-87-2.mol

Synonyms:N-Ethyl-N,4-dimethylbenzenamide;Benzenamide, N-ethyl-N,4-dimethyl-;35113-87-2;Ethylmethyl p-tolylamine;SCHEMBL8278827;DTXSID40188614;(S)-Methylethyl(4-methylphenyl)amine

Chemical Property of Benzenamide, N-ethyl-N,4-dimethyl-

Chemical Property:

• Vapor Pressure: 0.0633mmHg at 25°C
• Boiling Point: 231.1°Cat760mmHg
• Flash Point: 92.9°C
• Density: 0.931g/cm³
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 149.120449483
• Heavy Atom Count: 11
• Complexity: 103

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(C)C1=CC=C(C=C1)C

Technology Process of Benzenamide, N-ethyl-N,4-dimethyl-

There total 6 articles about Benzenamide, N-ethyl-N,4-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-(N-methylacetamido)toluene (612-03-3) → N-methyl-p-toluidine (623-08-5) + N-ethyl-N-methyl-4-methylaniline (35113-87-2)

Guidance literature:

With triethyl borane; Triethoxysilane; sodium hydroxide; In hexane; at 80 ℃; for 6h; Reagent/catalyst; Solvent; Inert atmosphere; Sealed tube;

Reference yield: 97.0%

4-(N-methylacetamido)toluene (612-03-3) → N-ethyl-N-methyl-4-methylaniline (35113-87-2)

Guidance literature:

With Triethoxysilane; sodium triethylborohydride; In hexane; at 80 ℃; for 6h; Schlenk technique; Glovebox; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.joc.9b02211

Reference yield: 95.0%

carbonic acid dimethyl ester (616-38-6) + N-ethyl-p-tolylamine (622-57-1) → N-ethyl-N-methyl-4-methylaniline (35113-87-2)

Guidance literature:

With [CpFe(CO)₂(1,3-bis-(2,4,6-trimethylphenyl)imidazol-2-ylidene)][I]; HSiPh₃; at 100 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1039/c4cc05517a

upstream raw materials:

N-ethyl-p-tolylamine

methyl iodide

4-(N-methylacetamido)toluene

carbonic acid dimethyl ester

Downstream raw materials:

N-ethyl-N-(p-tolyl)nitrous amide

N-methyl-N-nitroso-p-toluidine

4-(N-methylacetamido)toluene

N-ethyl-N-(4-methylphenyl)formamide

Refernces

• 1、 Yao, Wubing,He, Lili,Han, Deman,Zhong, Aiguo. "Sodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines". . . Retrieved 2019/11/14.
• 2、 Pan, Yixiao,Luo, Zhenli,Xu, Xin,Zhao, Haoqiang,Han, Jiahong,Xu, Lijin,Fan, Qinghua,Xiao, Jianliang. "Ru-Catalyzed Deoxygenative Transfer Hydrogenation of Amides to Amines with Formic Acid/Triethylamine". supporting information. p. 3800 - 3806. Retrieved 2019/07/12.